Results 241 to 250 of about 8,429,977 (311)

Review Article: Individualised Management of Reflux-Like Symptoms-Strategies Beyond Acid Suppression. [PDF]

Aliment Pharmacol Ther
Kahrilas PJ, Keefer L, Yadlapati R, Anastasiou F, Heidelbaugh JJ, Howden CW, Mendive JM, Savarino EV, Udrescu M, Hungin APS.   +9 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Biomarkers for diagnosis and prognosis of myelin oligodendrocyte glycoprotein antibody-associated disease - review article. [PDF]

Front Immunol
Sapana T, Zhuo Z.
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Review article: Use of prehospital early warning scores to predict short-term mortality: A systematic review. [PDF]

Emerg Med Australas
Naylor D, Dicker B, Howie G, Todd V.
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

A Review Article: The Relationship Between Obesity and Colorectal Cancer. [PDF]

Curr Diab Rep
Nguyen L, Shanmugan S.
europepmc   +1 more source

Neuromuscular Blocking Agents and Reversal Agents Usage, and Neuromuscular Blockade Monitoring in the Intensive Care Unit - Review Article. [PDF]

Int J Gen Med
Szewczyk M, Bieniecka A, Sobolewski K, Banasiak Ł, Grabarczyk Ł.   +4 more
europepmc   +1 more source

Review Article: Contemporary Transcatheter Heart Valves for TAVI in Bicuspid Aortic Anatomy. [PDF]

J Clin Med
Simopoulou C, Oliva O, Cesario V, Dumonteil N, Tchetche D, De Biase C.   +5 more
europepmc   +1 more source