The illusions of competition in the water sector: a response to the OFWAT/Cave consultations on introducing competition in the water sector in England and Wales [PDF]
, 2008 The paper provides a critical review of the role of liberalisation and competition in the water sector, based on empirical evidence from the UK and internationally. The paper is submitted as evidence to the official reviews of competition in water sector
Hall, David, Lobina, Emanuele
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Review: Electronic Music, Vol. III, Música Viva Competition Prize Winners 2004—2005—2006 [PDF]
, 2009 This collection, the third in a series from Miso Records in Portugal, collates the prizewinners of the Música Viva Competition from 2004 to 2006. The competition has assumed increasing importance on the international circuit, with 2006 being the seventh ...
Whalley, Ian
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Dynamics underlying Box-office: Movie Competition on Recommender Systems
, 2010 We introduce a simple model to study movie competition in the recommender systems. Movies of heterogeneous quality compete against each other through viewers' reviews and generate interesting dynamics of box-office.
B. R. Litman +3 more
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Balancing competition authorities’ investigative powers and fundamental rights in the EU legal order
Market and Competition Law ReviewCompetition authorities across the European Union wield extensive investigative powers in enforcing antitrust laws. These powers – including dawn raids, home searches and document seizures – can impinge upon fundamental rights such as privacy, the ...
Nuno Castro Marques
doaj +1 more source
Dancing on a Pin: Health Planning in Arizona [PDF]
, 2005 This publication challenges us to step back and reflect on the past, present and future of health systems. Take a deeper look at planning and how we got here, review the roles of competition and regulation, and learn about the health planning matrix ...
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LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
An analysis of the possible causes of product market malfunctioning in the EU: First results for manufacturing and service sectors [PDF]
Within the context of the follow-up to the Single Market Review, the European Commission has screened EU manufacturing and service sectors for problems of market malfunctioning. This paper investigates the nature of these problems in the selected sectors
Adriaan Dierx +2 more
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