Results 111 to 120 of about 2,301,879 (290)
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
An evolutionary model for simple ecosystems
, 1999 In this review some simple models of asexual populations evolving on smooth landscapes are studied. The basic model is based on a cellular automaton, which is analyzed here in the spatial mean-field limit.
Bagnoli, Franco, Bezzi, Michele
core +2 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Phenomenological Quantum Gravity
, 2005 These notes summarize a set of lectures on phenomenological quantum gravity which one of us delivered and the other attended with great diligence. They cover an assortment of topics on the border between theoretical quantum gravity and observational ...
Kimberly, Dagny, Magueijo, Joao
core +2 more sources
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Competitive intelligence: literature review
, 2005 Revisão de literatura sobre inteligência competitiva, levantada no Library & Information Science Abstracts (LISA) do período de 1969 a 2004, priorizando as publicações nacionais da área da Ciência da Informação e como estrangeira a Business Information Review, complementando com algumas publicações, não indexadas no LISA, porém relevantes na área.
openaire +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Birth, survival and death of languages by Monte Carlo simulation
, 2007 Simulations of physicists for the competition between adult languages since 2003 are reviewed. How many languages are spoken by how many people? How many languages are contained in various language families?
Schulze, C., Stauffer, D., Wichmann, S.
core +1 more source
The rise of emerging market multinationals and its impact on marketing [PDF]
, 2008 The purpose of this paper is to review and discuss the rise of emerging market multinationals (EMMs), with a special focus on its impact on marketing. Emerging market countries not only have millions newly affluent consumers and are also the home of a ...
Fan, Y
core
Twirling and Whirling: Viscous Dynamics of Rotating Elastica
, 1999 Motivated by diverse phenomena in cellular biophysics, including bacterial flagellar motion and DNA transcription and replication, we study the overdamped nonlinear dynamics of a rotationally forced filament with twist and bend elasticity.
A. E. H. Love +33 more
core +1 more source