Results 211 to 220 of about 2,658,581 (378)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Literature review of deteriorating inventory models by key topics from 2012 to 2015

, 2016
Larissa Janssen, Thorsten Claus, Jürgen Sauer   +2 more
openalex   +1 more source

Convergences and Gaps between Environmental Ethics, Climate Ethics, and Research Ethics: A Scoping Review. [PDF]

Sci Eng Ethics
Bourban M, Lenzi D, Sørensen MP, Fishberg R, Mehlich J, Fischbach F, Molina JL, Poague KIHM, Csábi A, Heffernan R, Hastings R, Rességuier A.   +11 more
europepmc   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Systematic Literature Review of Topic Labeling

Salma Mekaoui, Ilham Chaker, Arsalane Zarghili, Nikola S. Nikolov   +3 more
openalex   +1 more source

Gallstones, obesity, insulin resistance, and obstructive sleep apnea – current knowledge on the topic: A literature review [PDF]

Weronika Frosztęga, Maciej Sroczyński, Monika Michałek-Zrąbkowska, Mieszko Więckiewicz, Katarzyna Madziarska, Helena Martynowicz   +5 more
openalex   +1 more source

A Review of Scientific Topics and Literature in Abdominal Radiology in Germany – Part 2: Abdominal Parenchymal Organs [PDF]

, 2015
Lars Grenacher, Markus Juchems, K. Holzapfel, Sonja Kinner, T. Lauenstein, Johannes Weßling, A. Schreyer   +6 more
openalex   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Socio-Semantic X-Ray of Multi-Actor Constellations using Topics and Interstitial Authors: A Toolkit for Augmenting Computational Literature Reviews

Babajide Owoyele, Bhuvanesh Verma, Victor A. Omolaoye, Jonathan Antonio Edelman, Derk Loorbach, Gerard de Melo   +5 more
openalex   +1 more source

Changing Research Perspectives on the Global Health Workforce [PDF]

Past research on the health workforce can be structured into three perspectives – “health workforce planning” (1960 through 1970s); “the health worker as economic actor” (1980s through 1990s); and “the health worker as necessary resource” (1990s through ...
David Bloom, Till Bärnighausen
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