Results 41 to 50 of about 863,167 (248)

Monoflange custom-made partial pelvis replacements offer a viable solution in extensive Paprosky III defects: functional outcome and risk factor analysis in 79 cases

Bone & Joint Open
Aims: Custom-made partial pelvis replacements (PPRs) are increasingly used in the reconstruction of large acetabular defects and have mainly been designed using a triflange approach, requiring extensive soft-tissue dissection.
Yannik Hanusrichter, Carsten Gebert, Maximilian Steinbeck, Marcel Dudda, Jendrik Hardes, Sven Frieler, Lee M. Jeys, Martin Wessling   +7 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Clinical outcomes of the single-stage revision technique in conversion total hip arthroplasty after failed femoral neck fractures: a two-year follow-up study

Arthroplasty
Background Conversion to total hip arthroplasty (THA) is associated with higher rates of infection. The purpose of this study is to determine whether applying the surgical technique of single-stage revision can effectively reduce the infection rate of ...
Jiankang Pan, Yongqiang Sun, Shuailei Li
doaj   +1 more source

How often do we need offset stems for revision total knee arthroplasty? About a consecutive series of 789 knees

SICOT-J, 2023
Introduction: This study aimed to determine the incidence of offset stem usage in revision total knee arthroplasty (rTKA), and to assess the necessity for their use with the femoral and tibial components.
Vasiliadis Angelo V., Lording Timothy, Canetti Robin, Servien Elvire, Lustig Sébastien, Batailler Cécile   +5 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Mouldable Collagen–Tricalciumphosphate Is a Safe Carrier for Local Antibiotics—Short-Term Results in Revision Hip Arthroplasty

Antibiotics
Background: Improving local antibiotic delivery is a promising approach to improve infection control and potentially shorten systemic treatment in periprosthetic joint infection (PJI).
Yannik Hanusrichter, Carsten Gebert, Sven Frieler, Burkhard Moellenbeck, Marcel Dudda, Martin Wessling, Christoph Theil   +6 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Long non-coding RNAs in osteosarcoma: multifaceted regulators of malignancy and therapeutic resistance

Journal of Translational Medicine
Background Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents, with an annual incidence of approximately 3–4 cases per million.
Pei Liu, Weiwei Wang, Hong Zhang, Ming Qiang Liu, Jianlei Li, Yuanyin Teng, Kun Zhao, Anquan Shang, Yongqiang Sun   +8 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Joint preservation in revision arthroplasty and intercalary tumour implants using custom stem solutions

BMC Musculoskeletal Disorders
Background Off-the-shelf stems offer a wide variety of fixation methods for revision arthroplasty and intercalary tumour implants. However, in extensive defects or needed resection with minimal bone stock left, solid fixation is often not feasible with ...
Yannik Hanusrichter, Carsten Gebert, Sven Frieler, Ole Somberg, Marcel Dudda, Arne Streitbuerger, Jendrik Hardes, Martin Wessling   +7 more
doaj   +1 more source