Results 191 to 200 of about 75,615 (307)

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

open access: yesAdvanced Science, Volume 13, Issue 26, 8 May 2026.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu   +20 more
wiley   +1 more source

Current state of frailty in revision arthroplasty. [PDF]

open access: yesKnee Surg Relat Res
Kelly B   +8 more
europepmc   +1 more source

Traumatic Fracture of the Polyethylene Tibial Post in a Posterior‐Stabilized Total Knee Arthroplasty: A Case Report

open access: yesClinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Posterior‐stabilized total knee arthroplasty (TKA) uses a cam–post mechanism to provide anteroposterior stability, but polyethylene tibial post failure can occur as a rare yet serious complication. We report a case of early TKA failure caused by traumatic tibial post fracture.
Zhencan Han   +5 more
wiley   +1 more source

Oblique Bikini Incision Versus Longitudinal Incision for Direct Anterior Approach Total Hip Arthroplasty: A Systematic Review and Meta‐Analysis

open access: yesHealth Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Standard protocols for the direct anterior approach (DAA) typically employ a longitudinal incision, which violates Langer's lines and may compromise scar esthetics. The oblique “bikini” incision aims to improve cosmesis by following natural skin tension lines, but it raises anatomical concerns regarding iatrogenic lateral ...
Yi Leng, Jianzeng Zhang, Xin Qi
wiley   +1 more source

Optimized Protocol for the Isolation of UHMWPE Wear Debris by Lyophilization and Chemometric Identification (EDS/PCA)

open access: yesJournal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 114, Issue 5, May 2026.
An optimized protocol combining serum lyophilization, solid‐state alkaline digestion, and PCA‐assisted EDS analysis was validated for the analysis of UHMWPE wear debris. The method increased recovery yield by 20‐fold compared to liquid digestion and preserved particle morphology.
Luis Antonio da Costa Bento   +5 more
wiley   +1 more source

Internal fixation versus revision arthroplasty for Vancouver B2-B3 fractures: mortality and functional outcomes in frail patients. Insights from the PIPPAS study of 485 patients. [PDF]

open access: yesJ Orthop Traumatol
Moreta J   +151 more
europepmc   +1 more source

Acetabular Bone Preservation in H1 Ceramic Hip Resurfacing: A Comparison With A Conventional Metal‐on‐Metal Hip Resurfacing

open access: yesJournal of Orthopaedic Research, Volume 44, Issue 5, May 2026.
ABSTRACT This study compared the volume of acetabular bone resection between an anatomically designed cementless ceramic‐on‐ceramic hip resurfacing arthroplasty (H1HR) and metal‐on‐metal hip resurfacing (Birmingham Hip Resurfacing; BHR). We hypothesized that the anatomical design of the H1 cup would reduce the need for medialization to avoid rim ...
Yuki Yamamuro   +4 more
wiley   +1 more source

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