Results 251 to 260 of about 3,512,336 (402)

A pH‐Sensitive Nanosized Covalent–Organic Polymer for Enhanced Tumor Photodynamic Immunotherapy by Hypoxia Relief and STAT3 Inhibition

Advanced Science, EarlyView.
The nanosized covalent organic polymer composed of photosensitizer porphyrin, pyruvate kinase inhibitor vitamin K3, and STAT3 inhibitor WP1066 is prepared for enhanced photodynamic immunotherapy by simultaneous hypoxia relief and STAT3 inhibition. Abstract Photodynamic therapy (PDT) is a promising cancer therapy modality by generating reactive oxygen ...
Lei Lei, Wenbin Dai, Jinchao Zhao, Angfeng Jiang, Haisheng Peng, Qiao Jin, Xiaojing Li, Zhe Tang   +7 more
wiley   +1 more source

Revision surgery after failure of lateral unicompartmental knee replacement with a mobile-bearing device: a retrospective non -designer case-series. [PDF]

Arch Orthop Trauma Surg
Hariri M, Freytag J, Koch KA, Mick P, Nees T, Knappe K, Renkawitz T, Walker T.   +7 more
europepmc   +1 more source

Are abductor muscle quality and previous revision surgery predictors of constrained liner failure in hip arthroplasty?

, 2010
Michael G. Zywiel, Loi’y H. Mustafa, Peter M. Bonutti, Michael A. Mont   +3 more
openalex   +2 more sources

Revision Surgery for Vestibular Schwannomas

Skull Base, 2018
K. Peng, Brian S. Chen, M. Lorenz, G. Lekovic, M. Schwartz, W. Slattery, E. Wilkinson   +6 more
semanticscholar   +1 more source

Targeting Hyperglycemic Bone Pre‐Metastatic Niche for Breast Cancer Bone Metastasis Therapy

Advanced Science, EarlyView.
This study reveals that breast cancer creates a hyperglycemic pre‐metastatic niche in bone prior to colonization and amplifies glucose metabolism post‐metastasis. To target this mechanism, a biomimetic enzyme‐engineered nanoplatform that disrupts tumor glycolytic pathways, proposing a therapeutic strategy to inhibit breast cancer bone metastasis by ...
Jianxin Ye, Peng Hu, Rui Zhang, Lei Zhou, Zonghua Luo, Yanan Chen, Shengzhe Ruan, Mengyi Zhu, Huaze Ding, Yike Qian, Yan Xing, Tong Meng, Changping Wang, Dianwen Song   +13 more
wiley   +1 more source

Efficacy of an artificial intelligence preoperative planning system for assisting in revision surgery after artificial total hip arthroplasty. [PDF]

BMC Surg
Zhu J, Zheng S, Sun J, Ma B, Zhang C, Zhang C, Shen J, Xia T.   +7 more
europepmc   +1 more source

β‐Mangostin Attenuates TET2‐Mediated DNA Demethylation of Prkcg in the Prevention of Intervertebral Disc Degeneration

Advanced Science, EarlyView.
β‐Mangostin alleviates intervertebral disc degeneration through dual modulation of macrophage polarization and the TET2‐Prkcg axis in nucleus pulposus cells. Abstract Intervertebral disc degeneration (IDD) induced lower back pain is a main cause of disability, resulting in a substantial workforce loss worldwide and placing a substantial burden on the ...
Xiangzhen Kong, Hanwen Gu, Yuanqiang Zhang, Qunbo Meng, Qi Li, Kangle Song, Yanlin Li, Kaiwen Liu, Zhenchuan Liu, Rui Hu, Haoxi Zhai, Tian Li, Zemin Ling, Zhijian Wei, Fuxin Wei, Lei Cheng   +15 more
wiley   +1 more source

Patient Factors Associated with Recurrent Herniation and Revision Surgery following Lumbar Microdiscectomy. [PDF]

Spine Surg Relat Res
Hoang R, Song J, Tiao J, Ngan A, Hoang T, J Corvi J, K Namiri N, Chaudhary S, K Cho S, C Hecht A, Essig D, Virk S, D Katz A.   +12 more
europepmc   +1 more source

Revision knee replacement in England and Wales: an audit of hospital volume [PDF]

, 2013
Barrett J, DJ Deehan, MR Reed, National Joint Registry for England and Wales., Nv RC, PJ Gregg, PN Baker, RJ Critchley, S Hodgson, S Jameson   +9 more
core   +1 more source

Deciphering the Acetabular Labrum's Cellular Atlas: MDK Inhibition as a Novel Therapeutic Method for Developmental Dysplasia of the Hip

Advanced Science, EarlyView.
This study explores developmental dysplasia of the hip (DDH) by analyzing acetabular labrum abnormalities using single‐cell and spatial transcriptomics. Aberrant fibrocartilage stem cell proliferation is linked to DDH progression. Targeting the MK signaling pathway with a specific inhibitor effectively alleviates early DDH abnormalities, offering ...
Runze Yang, Huiling Liu, Minghao Ge, Dingyuan Zhang, Tianhao Xu, Lei Zhang, Yanlin Zhu, Shun Li, Jian Li, Xin Ma, Weili Fu   +10 more
wiley   +1 more source