Results 281 to 290 of about 3,512,336 (402)

Personalized Neoantigen Vaccine plus Regorafenib Increases Rgs2⁺CD8⁺ T Cells Infiltration and Reprograms the Tumor Microenvironment in Microsatellite Stable Colorectal Cancer Liver Metastases

Advanced Science, EarlyView.
This study synthesized a personalized neoantigen vaccine (Neo‐CRCVAS) and combined it with regorafenib, termed RegoNeo. This combination therapy significantly enhanced antitumor efficacy and promoted long‐term tumor‐specific immune memory in microsatellite stable colorectal cancer liver metastasis (MSS‐CRLM) models by increasing neoantigen‐specific ...
Hengkai Chen, Bin Chen, Yuanfeng Yang, Shoufeng Li, Huajun Cai, Zhicheng Zhuang, Yong Wu, Yuan Gao, Yupeng Chen, Xing Liu, Guoxian Guan, Jinfu Zhuang   +11 more
wiley   +1 more source

FOXM1 Protects Against Myocardial Ischemia‐Reperfusion Injury in Rodent and Porcine Models by Suppressing MKRN1‐Dependent LKB1 Ubiquitination

Advanced Science, EarlyView.
FOXM1 maintains mitochondrial bioenergetic function by inhibiting MKRN1‐mediated ubiquitination of LKB1 in cardiomyocytes. Loss of FOXM1 in cardiomyocytes results in upregulation of MKRN1, which enhances LKB1 ubiquitination and disrupts AMPK signaling and energy metabolism pathways. Conversely, FOXM1 overexpression preserves mitochondrial bioenergetics
Shuai Song, Xiaokai Zhang, Zihang Huang, Zhiqiang Pei, Linqi Zeng, Fengze Cai, Tongyao Wang, Mohan Li, Chenyan Liu, Yining Song, Jiahao Guo, Hao Lu, Xinyu Weng, Li Shen, Xiaochun Zhang, Xingxing Cai, Aijun Sun, Junbo Ge   +17 more
wiley   +1 more source

Analysis of Failed Posterior Fossa Decompression and an Effective Revision Surgery in Patients with Basilar Invagination and Atlantoaxial Dislocation. [PDF]

Orthop Surg
Qi M, Du Y, Zhang B, Xin Z, Zhang C, Liu Z, Guan J, Wang Z, Jian F, Duan W, Chen Z.   +10 more
europepmc   +1 more source

CIRCUMFERENTIAL PROXIMAL FEMORAL ALLOGRAFTS IN REVISION SURGERY ON TOTAL HIP ARTHROPLASTY: CASE REPORTS WITH A MINIMUM FOLLOW-UP OF 20 YEARS

, 2012
Bruno Dutra Roos, Milton Valdomiro Roos, Antero Camisa Júníor   +2 more
openalex   +1 more source

Reoperative pouch surgery for suspected Crohn's‐related complications aided by biologic coverage: Early experience from an inflammatory bowel disease center

Annals of Gastroenterological Surgery, EarlyView.
This paper demonstrates that revisional/redo ileal pouch anal anastomosis (IPAA) surgery with concurrent biologic therapy provides a viable, stoma‐free alternative for patients with Crohn's disease‐like complications, showing a high functioning pouch rate and expanding options for managing pouch failure.
Mehmet Gulmez, Daniel J. Wong, Ariela K. Holmer, Eren Esen, Shannon Chang, Arman Erkan, David Hudesman, Andre da Luz Moreira, Feza H. Remzi   +8 more
wiley   +1 more source

Short‐ and Long‐Term Outcomes of Open, Laparoscopic, and Robot‐Assisted Surgery for Rectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
Robot‐assisted rectal resection demonstrated superior short and long‐term outcomes compared to laparoscopic and open approaches. ABSTRACT Background Robot‐assisted surgery has short‐term benefits in rectal cancer surgery; however, its long‐term advantages remain unclear. This study compared short‐ and long‐term outcomes of open, laparoscopic, and robot‐
Marie Hanaoka, Hiroyasu Kagawa, Ataru Igarashi, Hiroshi Yoshihara, Shinichi Yamauchi, Masanori Tokunaga, Lin Peng‐Lin, Minkyung Shin, Yusuke Kinugasa   +8 more
wiley   +1 more source

Revision Surgery Is the Most Common Definition of Failure in Studies Evaluating Knee Cartilage Restoration Outcomes: A Systematic Review. [PDF]

Arthrosc Sports Med Rehabil
Farrington L, Trotter M, Goodrich E, Tarakemeh A, Henkelman E, Schroeppel P, Bernard CD, Long R, Morey T, White J, Vopat BG.   +10 more
europepmc   +1 more source

Intramedullary knee spacer in 2-stage revision knee surgery with segmental bone loss

, 2012
Henrik M. Schrøder, Michael Mørk Petersen   +1 more
openalex   +2 more sources

Association Between Cholecystectomy and Gastric Cancer in a Cohort Study in Taiwan

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Objective The association between cholecystectomy and gastric cancer is undetermined. The objective of this study was to assess whether subjects with cholecystectomy are at risk of gastric cancer in Taiwan. Methods This study used data from a cohort of 2 000 000 beneficiaries over a twelve‐year period (2010–2021) from the Taiwan National ...
Kuan‐Fu Liao, Cheng‐Chan Yu, Sheng‐Chun Chiu, Yu‐Hung Kuo, Shih‐Wei Lai   +4 more
wiley   +1 more source

Finite element analysis of two-level discontinuous cervical hybrid revision surgery strategy to reduce biomechanical responses of adjacent segments. [PDF]

JOR Spine
Liang W, Sun D, Han B, Yang Y, Yin P, Hai Y.   +5 more
europepmc   +1 more source