Results 31 to 40 of about 2,102,678 (308)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Mouldable Collagen–Tricalciumphosphate Is a Safe Carrier for Local Antibiotics—Short-Term Results in Revision Hip Arthroplasty

Antibiotics
Background: Improving local antibiotic delivery is a promising approach to improve infection control and potentially shorten systemic treatment in periprosthetic joint infection (PJI).
Yannik Hanusrichter, Carsten Gebert, Sven Frieler, Burkhard Moellenbeck, Marcel Dudda, Martin Wessling, Christoph Theil   +6 more
doaj   +1 more source

Contemporary indications for first-time revision surgery after primary cementless total hip arthroplasty with emphasis on early failures

Journal of Orthopaedic Surgery and Research, 2021
Background To clarify contemporary indications for first-time revision surgery after primary cementless total hip arthroplasty (THA) for addressing potential issues with cementless THA.
Goro Motomura, Satoshi Hamai, Satoshi Ikemura, Masanori Fujii, Shinya Kawahara, Soichiro Yoshino, Yasuharu Nakashima   +6 more
doaj   +1 more source

Revision Surgery of the Cleft Palate

Seminars in Plastic Surgery, 2020
AbstractCleft palate repairs often require secondary surgeries and/or revisions for a variety of reasons. The most common causes are symptomatic oronasal fistulas and velopharyngeal insufficiency. Complications from primary surgery, such as wound dehiscence, infection, and hematomas, contribute to the relatively high rate of revision surgery ...
Shirley, Hu, Jared, Levinson, Joseph J, Rousso   +2 more
openaire   +3 more sources

The Outcomes of Bleb Revision Surgery Techniques After Trabeculectomy

, 2012
Pur po se: To evaluate the techniques and the results of revision surgeries in order to manage bleb failure after trabeculectomy. Ma te ri al and Met hod: The records of 23 eyes who had undergone bleb revision surgery because of bleb failure after ...
Mustafa Koç, Orhan Ayar, Kemal Özülken, Hikmet Hasıripi, Ahmet Karakurt, Yaran Koban   +5 more
core   +1 more source

Preoperative visual acuity among cataract surgery patients and countries' state of development: a global study. [PDF]

, 2011
OBJECTIVE: To describe the preoperative surgical case mix among patients undergoing cataract extraction and explore associations between case mix, country level of development (as measured by the Human Development Index, HDI) and cataract surgery rates ...
Razavi, H, Turner, EL, Claire Gilbert, Robert J Lindfield, Robert Lindfield, Lindfield, Robert J, Shaheen Shah, Elizabeth Turner, Gilbert, Clare E, Int Eye Res, N, International Eye Research Network, Shah, SP, Claire E Gilbert, Razavi, Hessom, Shaheen P Shah, Hessom Razavi, Elizabeth L Turner, Gilbert, CE, Shah, Shaheen P, Turner, Elizabeth L, Lindfield, RJ, on behalf of the International Eye Research Network, Gilbert, Claire E   +22 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Predictors and tactics for revision surgery in lateral lumbar interbody fusion

BMC Musculoskeletal Disorders, 2022
Background The purpose of this study is to analyze the factors affecting the revision of lateral lumbar interbody fusion (LLIF), and to summarize the complications and decision-making strategies for revision surgery after LLIF. Methods We retrospectively
Weijian Wang, Jiaqi Li, Yafei Xu, Yun Luo, Wenyuan Ding, Wei Zhang   +5 more
doaj   +1 more source