Results 71 to 80 of about 496,119 (359)

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

The Impact of Tilburg Frailty on Poststroke Fatigue in First‐Ever Stroke Patients: A Cross‐Sectional Study With Unified Measurement Tools and Improved Statistics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Poststroke fatigue (PSF) and frailty share substantial overlap in their manifestations, yet previous research has yielded conflicting results due to the use of heterogeneous frailty assessment tools. Objective To evaluate the independent impact of frailty on PSF using a unified measurement system (Tilburg Frailty Indicator, TFI ...
Chuan‐Bang Chen, Xiao‐Xue Wang, Shao‐Rui Bao, Sui‐Li Lin, Mei‐Chun Shu, Xi‐Xi Ye, Wen‐Jie Cong   +6 more
wiley   +1 more source

Prediction of Myasthenia Gravis Worsening: A Machine Learning Algorithm Using Wearables and Patient‐Reported Measures

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare disorder characterized by fluctuating muscle weakness with potential life‐threatening crises. Timely interventions may be delayed by limited access to care and fragmented documentation. Our objective was to develop predictive algorithms for MG deterioration using multimodal telemedicine data ...
Maike Stein, Haoqi Sun, Sophie Lehnerer, Lea Gerischer, Maximilian Mönch, Christian Meisel, Andreas Meisel, Pushpa Narayanaswami   +7 more
wiley   +1 more source

The use of an ultrasonic cement removal device in revision hip and knee arthroplasty—A matched case‐control study

Journal of Experimental Orthopaedics
Purpose The objective of this case series was to investigate the effect of ultrasound‐guided cement removal devices on operating time and patient safety in the revision of cemented knee and hip arthroplasties. Methods A total of 11 cases were examined in
Marco Haertlé, Lars‐René Tücking, Alexander Derksen, Magnus Reulbach, Eike Jakubowitz, Henning Windhagen   +5 more
doaj   +1 more source

Outcomes following reoperative bariatric surgery following laparoscopic sleeve gastrectomy at a tertiary care centre

Journal of Minimal Access Surgery
Introduction: Laparoscopic sleeve gastrectomy (SG) is the most common bariatric surgical procedure worldwide. Approximately 20%–30% of patients present with weight loss failure or reflux following SG, which might require reoperative surgery.
Vitish Singla, Sukhda Monga, Arun Kumar, Tamoghna Ghosh, Bhanu Yadav, Mehul Gupta, Amardeep Kumar, Lokesh Kashyap, Vineet Ahuja, Sandeep Aggarwal   +9 more
doaj   +1 more source

Will Memantine Exacerbate Seizures in People With Epilepsy? A Prospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate whether add‐on memantine would exacerbate seizures in people with epilepsy. Methods This was a prospective cohort study. People with epilepsy diagnosed with cognitive impairment were consecutively invited. Those who agreed were followed up for at least 24 weeks.
Peiyu Wang, Lu Lu, Hui Gao, Qi Zhang, Jing Xiao, Josemir W. Sander, Weixi Xiong, Dong Zhou   +7 more
wiley   +1 more source

Cost-Effectiveness of Corrective Fusion Surgeries for Adult Spinal Deformities: Does Unexpected Revision Surgery Affect Cost-Effectiveness?

Spine Surgery and Related Research
Introduction: Previous research has demonstrated that mid- to long-term health-related quality of life following corrective fusion surgery for adult spinal deformity (ASD) can be improved by appropriate revision surgery.
Hideyuki Arima, Tomohiko Hasegawa, Yu Yamato, Masashi Kato, Go Yoshida, Tomohiro Banno, Shin Oe, Koichiro Ide, Tomohiro Yamada, Keiichi Nakai, Kenta Kurosu, Yukihiro Matsuyama   +11 more
doaj   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

ASSESSMENT OF THE RESULTS OF REVISION HIP AND KNEE REPLACEMENT SURGERY IN CASE OF PERIPROSTHETIC INFECTION

Байкальский медицинский журнал
Background. Periprosthetic infection is a serious complication of large joint replacement surgery. To date, there is no consensus on the choice of surgical tactics for treating this category of patients.The aim of the work. To determine the effectiveness
Alexey L. Kameka, Alexey N. Grishchuk, Svetlana N. Leonova   +2 more
doaj   +1 more source

Implementation of a quality improvement project on smoking cessation reduces smoking in a high risk trauma patient population. [PDF]

, 2016
BackgroundCigarette smoking causes about one of every five deaths in the U.S. each year. In 2013 the prevalence of smoking in our institution's trauma population was 26.7 %, well above the national adult average of 18.1 % according to the CDC website. As
Carrens, Karen, Doben, Andrew, Gross, Ronald, Korntner, Samuel, Nahmias, Jeffry, Poola, Shiva   +5 more
core   +1 more source