Operação cappuccino: os galegos, os cromos, os saldos, as vitaminas e os bacocos!...
Íamos até à Galiza por meia dúzia de dias. Assim sendo, apanhámos o comboio para Vigo no Porto, na velhinha Estação de São Bento. Logo aqui começa a primeira surpresa, aquando da aquisição do bilhete, quando o solícito funcionário da CP nos disse que a ...
Maria da Conceição Duarte Pereira
doaj
[Evidence of effectiveness of hospital transition care in the elderly: rapid systematic reviewEvidencia de la eficacia de la atención transitoria prestada a las personas mayores después de la hospitalización: revisión sistemática rápida]. [PDF]
Uchimura LYT+5 more
europepmc +1 more source
ABSTRACT Background Sphingosine‐1‐phosphate receptor modulators (S1PRM) are used to treat relapsing multiple sclerosis (MS). Each drug has a different S1PR‐subtype selectivity. They target the G‐protein coupled S1P receptors and exert significant immunomodulatory effects, such as preventing the formation of new CNS lesions and the reactivation of pre ...
Faizan Shahzad+8 more
wiley +1 more source
ABSTRACT Objective Malignant gliomas pose significant therapeutic challenges. This study aimed to identify and characterize a novel chimeric RNA in glioma and assess its clinical and functional significance for precision treatment. Methods The C19orf47‐AKT2 chimeric RNAs were identified through RNA sequencing and validated by polymerase chain reaction.
Zihan Wang+11 more
wiley +1 more source
Text-book of the Embryology of the Invertebrates . By Dr. E. Korschelt and Dr. K. Heider. Translated from the German by Matilda Bernard, revised and edited with additional notes by Martin F. Woodward. Vols. II. and III. London, Swan, Sonnenschein & Co.; New York, The Macmillan Co. 1899 [PDF]
William Morton Wheeler
openalex +1 more source
In Vitro Modeling of Natural Killer Cell Cytotoxicity to Inform Personalized ALS Therapeutics
ABSTRACT Objective Natural killer (NK) cells might contribute to motor neuron death in amyotrophic lateral sclerosis (ALS) through direct cytotoxicity, a process that could be inhibited with the FDA‐approved JAK/STAT pathway inhibitor, tofacitinib. This study aimed to verify that tofacitinib can suppress NK cell cytotoxicity, investigate if immune cell
Benjamin J. Murdock+8 more
wiley +1 more source
A Validated Model to Predict Severe Weight Loss in Amyotrophic Lateral Sclerosis
ABSTRACT Severe weight loss in amyotrophic lateral sclerosis (ALS) is common, multifactorial, and associated with shortened survival. Using longitudinal weight data from over 6000 patients with ALS across three cohorts, we built an accelerated failure time model to predict the risk of future severe (≥ 10%) weight loss using five single‐timepoint ...
David G. Lester+4 more
wiley +1 more source