Results 51 to 60 of about 19,427 (285)

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

Advanced Science, EarlyView.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu, Jinqiu Liu, Yuxuan Deng, Shuyu Hao, Xiaoli Zhang, Mingxu Yang, Chao Guo, Chao Du, Yingdan Chen, Tai Sun, Nan Ji, Zhengping Zhuang, Jie Feng   +12 more
wiley   +1 more source

Key Management in Wireless Sensor Networks

Journal of Sensor and Actuator Networks, 2015
Wireless sensor networks are a challenging field of research when it comes to security issues. Using low cost sensor nodes with limited resources makes it difficult for cryptographic algorithms to function without impacting energy consumption and latency.
Ismail Mansour, Gérard Chalhoub, Pascal Lafourcade   +2 more
doaj   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

Selenophene π‐Core Fusion for Simultaneous Fast Reverse Intersystem Crossing and Narrowband Long‐Wavelength TADF

Angewandte Chemie, EarlyView.
Dibenzo[b,d]selenophene (DBSe) π‐core fusion enables rapid triplet–singlet interconversion while preserving the narrowband emission features of multi‐resonance thermally activated delayed fluorescence (MR‐TADF) luminogens. Combined with peripheral donor engineering, this strategy enables systematic emission tuning from green to red, leading to highly ...
Jingpeng Zhang, Jun Hyeon Lee, Guanting Liu, Tatsuya Mori, Takuma Yasuda   +4 more
wiley   +2 more sources

Cobalt‐Catalyzed Asymmetric Construction of Boron Stereocenters With C–N Axial Chirality

Advanced Science, EarlyView.
A cobalt/Salox‐catalyzed one‐pot annulation enables enantioselective formation of B‐stereogenic centers and C─N axial chirality via C─H/N─H annulation, affording diverse fluorescent products with high stereocontrol and optoelectronic potential. ABSTRACT The efficient construction of boron stereogenic centers alongside axial chirality remains a ...
Subramani Kumaran, Harihara Subramanian Ravi Sankar, Pritam Maity, J. Richard Premkumar, Abir Das, Basker Sundararaju   +5 more
wiley   +1 more source

Cobalt‐Catalyzed C─N Bond Formation via Metal‐Hydride Hydrogen Atom Transfer (MHAT)

Angewandte Chemie, EarlyView.
Cobalt‐catalyzed metal‐hydride hydrogen atom transfer (Co‐MHAT) converts simple alkenes into C─N bonds under mild, near‐neutral conditions. A shared Co─H‐initiated radical/organocobalt intermediate is channeled into radical trapping, radical‐polar crossover, or radical ligand transfer, unifying hydroamination, hydroazidation, hydroamidation, and remote
Arman Khosravi, Ming‐Yu Ngai
wiley   +2 more sources

CONSIDERATIONS CONCERNING THE REVOCATION OF ADMINISTRATIVE ACTS WHICH ARE CONTRARY TO EUROPEAN UNION LAW [PDF]

Challenges of the Knowledge Society, 2012
In the process of adopting administrative acts, public authorities are obliged to respect both the national provisions legally superior and European Union law with superior legal force and also the general principles of law, including those imposed by ...
CONSTANTA MATUSESCU
doaj  

Uhrf1‐Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease

Advanced Science, EarlyView.
Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang, Xin‐Rong Xu, Hui‐Lin Zhang, Qi‐Meng Zhu, Xin‐Yuan Li, Xi‐Peng Shang, Jing‐Hui Du, Christophe Morisseau, Feng Qiu, Cheng‐Peng Sun   +9 more
wiley   +1 more source

Catalyst‐Controlled Divergent Strain‐Release Amination and Skeletal Remodeling of Bicyclo[1.1.0]Butanes

Angewandte Chemie, EarlyView.
Catalyst‐controlled nitrene transfer unlocks divergent reactivity of bicyclo[1.1.0]butanes. Rhodium catalysis promotes selective strain‐release amination to access cyclobutene and cyclobutane amino‐acid scaffolds, whereas visible‐light photocatalysis redirects nitrene reactivity toward double amination and skeletal remodeling, providing a complementary
Aksar Ali, Lennard Kloene, Justus Koedel, Yifan Guo, Minakshi Altia, Rene M. Koenigs   +5 more
wiley   +2 more sources

Revocation Games in Ephemeral Networks [PDF]

A frequently proposed solution to node misbehavior in mobile ad hoc networks is to use reputation systems. But in ephemeral networks - a new breed of mobile networks where contact times between nodes are short and neighbors change frequently ...
Felegyhazi, Mark, Hubaux, Jean-Pierre, Raya, Maxim, Manshaei, Mohammad Hossein   +3 more
core   +2 more sources