Results 81 to 90 of about 211,194 (283)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
ReligionsThe confrontation between Greek philosophy and the Biblical heritage has led to a wealth of different currents, varying from Christian and Jewish neo-Platonism to religious convictions that proclaim a complete rupture between creation and the highest ...
Marcel Poorthuis
doaj +1 more source
Adhuc Tacfarinas: the causes of the Tiberian war in North Africa (AD ca. 15-24) and the impact of the conflict on Roman imperial policy [PDF]
, 2015 During the reign of Tiberius successive governors of Africa Proconsularis struggled to suppress a serious revolt by a number of semi-nomadic tribes led by Tacfarinas.
Vanacker, Wouter
core +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Nationhood and Constitutionalism in the Dutch Republic: An Examination of Grotius' Antiquity of the Batavian Republic [PDF]
, 2017 The emphasis in contemporary democratic theory and in the history of political thought on the ‘natural rights’ theory of popular sovereignty of Locke, precursors of which are found in the work of Hugo Grotius and others, obscures
Alexander-Davey, Ethan
core
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
April Fools’ Day, A Celebration of All Things Creative
, 2015 April Fools\u27 Day is unique among our holidays because it is the only one for which ingenuity is required. Other festivals are celebrated with expectations of prepackaged icons.
Gimbel, Steven
core