Results 51 to 60 of about 720,075 (308)

"Revolution? What Revolution?" Successes and limits of computing technologies in philosophy and religion [PDF]

, 2004
Computing technologies like other technological innovations in the modern West are inevitably introduced with the rhetoric of "revolution". Especially during the 1980s (the PC revolution) and 1990s (the Internet and Web revolutions), enthusiasts ...
Ess, Charles
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

The Mythologization of the Abrek's Image in the Modern Caucasian Linguistic Consciousness

Astra Salvensis, 2019
The modern realities of our world actualize the phenomenon of the militant, accentuating the primary fears of the recipient before uncontrolled power, lack of spirituality, darkness, etc.
Irina S. KARABULATOVA, Svetlana A. LYAUSHEVA, Zaineta R. KHACHMAFOVA, Irina P. SAVCHUK, Oksana S. SHIBKOVA   +4 more
doaj  

Seasonal and gendered patterns in subsistence fishing and shellfish gathering: insights from Mfumbwi (Zanzibar) for archaeological interpretation and contemporary fisheries management

Frontiers in Environmental Archaeology
The village of Mfumbwi (Jambiani, Zanzibar Island) is home to maritime fishers and shellfish gatherers who use traditional methods to harvest marine fauna for subsistence.
Akshay Sarathi, Patrick Faulkner, Benjamin J. Linzmeier, Abdallah K. Ali, Haji Othman, Ally Ussi   +5 more
doaj   +1 more source

Three-Dimensional Printing-A Revolutionary Technology [PDF]

Journal of Clinical and Diagnostic Research, 2018
Three-dimensional printing has been hailed as a path-breaking technology which will change manufacturing. It is used in aerospace, defence, art and design, 3D printing is becoming a subject of interest in medical and dental fields.
Kanchan Rajkumari, Poornima Chandra, Pachipulusu Balaji   +2 more
doaj   +1 more source

The French Revolution and early European revolutionary terrorism [PDF]

, 2015
This chapter discusses some of the antecedents to the 'Terror' in the French Revolution before exploring the relationship between different forms of political terror in the 1790s in revolutionary France.
Rapport, Mike
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Context and Progress of Domestic and International Low-Altitude Economic Research Based on the CiteSpace Software

Redai dili
As an important economic form for the innovation and development of human society, since the 21st century, the low-altitude economy has become one of the key ways to promote China's modern industrial development, with its unique charm and broad ...
Liao Wang, Cao Xiaoshu, Yuan Liyang, Zhong Zhiping   +3 more
doaj   +1 more source