Results 61 to 70 of about 17,225 (252)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Anticipation of Social and Monetary Rewards in Schizophrenia

Journal of Psychiatry, 2017
Numerous behavioural and neuroimaging studies have explored human cognitive processing of various rewards, such as food, monetary or social stimuli. Previous studies with patients suffering from schizophrenia (SZ) used incentive delay tasks with monetary rewards.
Bernd Hanewald, Franziska Behrens, Harald Gruppe, Gebhard Sammer, Bernd Gallhofer, Soeren Krach, Frieder Michel Paulus, Lena Rademacher, Jona Ruben Iffland   +8 more
openaire   +1 more source

The neural code of reward anticipation in human orbitofrontal cortex [PDF]

Proceedings of the National Academy of Sciences, 2010
An optimal choice among alternative behavioral options requires precise anticipatory representations of their possible outcomes. A fundamental question is how such anticipated outcomes are represented in the brain. Reward coding at the level of single cells in the orbitofrontal cortex (OFC) follows a more heterogeneous coding scheme than suggested by ...
Kahnt, T., Heinzle, J., Park, S., Haynes, J.   +3 more
openaire   +3 more sources

Examining neural responses to anticipating or receiving monetary rewards and the development of binge eating in youth. A registered report using data from the Adolescent Brain Cognitive Development (ABCD) study

Developmental Cognitive Neuroscience
Binge eating is characterized as eating a large amount of food and feeling a loss of control while eating. However, the neurobiological mechanisms associated with the onset and maintenance of binge eating are largely unknown. Recent neuroimaging work has
Cassandra J. Lowe, Lindsay P. Bodell
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Neural responses to monetary incentives in bipolar disorder

NeuroImage: Clinical, 2019
Although behavioral sensitivity to reward predicts the onset and course of mania in bipolar disorder, the evidence for neural abnormalities in reward processing in bipolar disorder is mixed.
Sheri L. Johnson, Hershel Mehta, Terence A. Ketter, Ian H. Gotlib, Brian Knutson   +4 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

An Electrophysiology Protocol to Measure Reward Anticipation and Processing in Children [PDF]

Journal of Visualized Experiments, 2018
We present a protocol designed to measure the neural correlates of reward in children. The protocol allows researchers to measure both reward anticipation and processing. Its purpose is to create a reward task that is appropriate for young children with and without autism while controlling reward properties between two conditions: social and nonsocial.
Stavropoulos, Katherine KM, Carver, Leslie J   +1 more
openaire   +4 more sources

Peripheral immune cell reactivity and neural response to reward in patients with depression and anhedonia

Translational Psychiatry, 2021
Increased levels of peripheral cytokines have been previously associated with depression in preclinical and clinical research. Although the precise nature of peripheral immune dysfunction in depression remains unclear, evidence from animal studies points
Sara Costi, Laurel S. Morris, Abigail Collins, Nicolas F. Fernandez, Manishkumar Patel, Hui Xie, Seunghee Kim-Schulze, Emily R. Stern, Katherine A. Collins, Flurin Cathomas, Michael K. Parides, Alexis E. Whitton, Diego A. Pizzagalli, Scott J. Russo, James W. Murrough   +14 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source