Results 51 to 60 of about 1,011,379 (271)
Personalizing Task-oriented Dialog Systems via Zero-shot Generalizable Reward Function [PDF]
, 2022 A. B. Siddique +3 more
openalex +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Neuronal and psychological underpinnings of pathological gambling [PDF]
, 2014 Like in the case of drugs, gambling hijacks reward circuits in a brain which is not prepared to receive such intense stimulation. Dopamine is normally released in response to reward and uncertainty in order to allow animals to stay alive in their ...
Anselme +18 more
core +3 more sources
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Extending the Logic IM-SPDL with Impulse and State Rewards [PDF]
, 2007 This report presents the logic SDRL (Stochastic Dynamic Reward Logic), an extension of the stochastic logic IM-SPDL, which supports the specication of complex performance and dependability requirements.
Haverkort, Boudewijn R., Kuntz, Matthias
core +1 more source
Fat and lean tissue accretion in relation to reward motivation in children [PDF]
, 2016 ‘Reward sensitivity’ explains inter-individual differences in the motivation to obtain rewards when reward cues are perceived. This psychobiological trait has been linked to higher consumption of palatable food when exposed to palatable food cues.
Braet, Caroline +7 more
core +2 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Event-related potential studies of outcome processing and feedback-guided learning
Frontiers in Human Neuroscience, 2012 In order to control behavior in an adaptive manner the brain has to learn how some situations and actions predict positive or negative outcomes. During the last decade cognitive neuroscientists have shown that the brain is able to evaluate and learn from
René eSan Martín +2 more
doaj +1 more source
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Fronto-striato network function is reduced in major depressive disorder
Frontiers in PsychiatryIntroductionMajor depressive disorder (MDD) is a major cause of poor quality of life and disability and is highly prevalent worldwide. Various pathological mechanisms are implicated in MDD, including the reward system.
Reoto Kijima +6 more
doaj +1 more source