Viscosity of concentrated mRNA solutions: Implications for downstream processing
Abstract Messenger RNA (mRNA) therapeutics can be used to protect against infectious disease and for the treatment of cancers and genetic disorders. In order to obtain the desired therapeutic dosage, it is necessary to concentrate the mRNA to levels where the viscosity of the mRNA solutions can become significant.
Amin Javidanbardan +3 more
wiley +1 more source
Electroosmosis and Solute Diffusion Transport of Maxwell Fluid Through a Polyelectrolyte-Grafted Microchannel with Modulated Charged Surfaces. [PDF]
Shang Y, Li F, Yang C.
europepmc +1 more source
From Confusion to Clarity: A Multi‐Stage Process Framework for Understanding Consumer Confusion
ABSTRACT This paper reconceptualizes consumer confusion as a multi‐stage temporal process rather than a static outcome, addressing theoretical fragmentation in existing antecedent‐consequence models. By integrating cognitive appraisal, contextual amplification, and adaptive coping within a unified framework, we explain how confusion unfolds rather than
Fatih Celik, Erdogan Koc
wiley +1 more source
Numerical Study of Entropy Production in a Fluidic Oscillator. [PDF]
Dávalos JO +4 more
europepmc +1 more source
Automated Process Optimization in a Novel Triple Shaft Mixer with Adaptive Mixing Modes
A novel multi‐purpose mixer with adjustable blade angle and a coaxial stirrer is developed, providing three degrees of freedom. An optimization strategy is integrated to autonomously identify optimal operating conditions through automated tests. The current draw of the main stirrer serves as the optimization criterion, while stirrer speeds, directions,
B. Schwarz, H. Kniele, J. A. Lindner
wiley +1 more source
ASP-assisted symbolic regression for interpretable modelling of 3D laminar channel flow. [PDF]
Aravanis T +4 more
europepmc +1 more source
The Filament Extension Atomization Process for Powder Production of Elastic Fluids
Filament extension atomization is a promising technique for spraying a wide range of materials, enabling narrow droplet size distributions. This study examines the behavior of various fluids and suspensions to define application limits and identify optimal operating conditions.
Moritz Neukötter +4 more
wiley +1 more source
Peristaltic transport of magnetized multi-metallic hybrid nanofluid flow with thermal radiation for heat transfer enhancement. [PDF]
Tanveer A +3 more
europepmc +1 more source
Thermal defrosting limits desublimator efficiency in freeze‐drying. This review and case study compares thermal versus mechanical regeneration, links frost properties and external heat transfer to energy demand, and summarizes pilot‐scale scraping results enabling single‐unit, continuous lyophilization.
Moritz Krummenacher +3 more
wiley +1 more source
Shear-free, inhomogeneous turbulence in a stably stratified fluid. [PDF]
Hass R, Lele S.
europepmc +1 more source

