Detergent/surfactant retention during ultrafiltration in the formulation of biotherapeutics
Abstract Surfactants like polysorbate (Tween®) are commonly used as excipients in the production of monoclonal antibodies and other recombinant proteins. The retention behavior of these excipients in the final ultrafiltration step can be difficult to predict due to the presence of both monomers and micelles.
Liang‐Kai Chu+4 more
wiley +1 more source
Efficient propagation of suspended HL-60 cells in a disposable bioreactor supporting wave-induced agitation at various Reynolds number. [PDF]
Wierzchowski K, Grabowska I, Pilarek M.
europepmc +1 more source
Abstract One strategy to enhance the production of biological therapeutics is using transient perfusion in the preculture (N‐1 stage) to seed the production culture (N stage) at ultra‐high cell densities (>10 x 106 viable cells/mL). This very high seeding density improves cell culture performance by shortening the timeline and/or achieving higher final
Lucas Lemire+5 more
wiley +1 more source
Soft, skin‐interfaced microfluidic systems exploit biodegradable thermoplastic copolyester elastomers for the microfluidic layers, cellulose films and pressure sensitive adhesives as sealing layers, and carefully selected chemical reagents as colorimetric assays for monitoring sweat loss, sweat rate, pH, and chloride concentration.
Shanliangzi Liu+8 more
wiley +1 more source
Discussion: “On the Evaluation of Reynolds Number and Relative Surface Roughness Effects on Centrifugal Compressor Performance Based on Systematic Experimental Investigations” (Simon, H., and Bu¨lska¨mper, A., 1984, ASME J. Eng. Gas Turbines Power, 106, pp. 489–498) [PDF]
F. J. Wiesner
openalex +1 more source
Morphology of the dysplastic hip and the relationship with sex and acetabular version
Abstract The dysplastic hip is characterized by incomplete coverage of the femoral head, resulting in increased risk of early osteoarthritis. The morphological variation of the hip joint is diverse and clear differences exist between females and males.
Inger Mechlenburg+6 more
wiley +1 more source
Nusselt number and friction factor in zig-zag microchannels subjected to constant heat flux
This study quantifies the heat transfer coefficient, pressure drop, Nusselt number and friction factor associated with flow of water in zig-zag microchannels, with square cross-section and sharp edges, when subjected to constant heat flux boundary ...
Bobby Mathew+5 more
doaj
Hydrodynamics of metachronal paddling: effects of varying Reynolds number and phase lag. [PDF]
Ford MP+3 more
europepmc +1 more source