Results 91 to 100 of about 118,582 (236)

Higher Body Mass Index Is a Causal Risk Factor for Skin Infections: A Mendelian Randomisation Study Using UK Biobank and FinnGen

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Infections remain a leading cause of mortality and morbidity globally. We aimed to evaluate the potential causal role of higher BMI on common bacterial, viral and fungal infections using Mendelian randomisation (MR). Material and Methods In UK Biobank (N = 502 131, N = 230 542 with linked GP records), we tested observational associations ...
Rhian Hopkins, Ethan de Villiers, Michael N. Weedon, Beverley M. Shields, John M. Dennis, Andrew P. McGovern, Harry D. Green   +6 more
wiley   +1 more source

Ligand‐specific tuning of CLEC10A signalling strength and dendritic cell responses through engagement of different GalNAc‐containing glycan structures

The FEBS Journal, EarlyView.
The authors investigated the effects of various glycan ligands for CLEC10A, a lectin receptor expressed on dendritic cells (DCs). Monocyte‐derived DCs were stimulated with glycan‐conjugated dendrimers in combination with the TLR1/2 ligand Pam3CysK4, and responses were investigated at the mRNA and protein level.
Nadia L. van der Meijs, Remi Hatinguais, Mike de Kok, R. J. Eveline Li, Tesfay M. Godefa, Victor L. J. L. Thijssen, Yvette van Kooyk, Sandra J. van Vliet   +7 more
wiley   +1 more source

Sea Lice (Lepeophtheirus salmonis) Harbour Putative Fish Pathogens: Insights From Illumina and Nanopore Sequencing

Journal of Fish Diseases, EarlyView.
ABSTRACT Ectoparasites that penetrate host skin can act as biological or mechanical vectors for pathogens and, in some cases, serve as reservoirs. Crustacean ectoparasites of fish are potential vectors of pathogens, which is especially relevant for obligate pathogens (e.g., Aeromonas salmonicida) with limited seawater survival. Sea lice (Lepeophtheirus
B. Klimesova, N. M. Ruane, R. Domingo‐Bretón, F. Moroni, F. Naya‐Català, J. Pérez‐Sánchez, K. O'Dwyer, O. Lyashevska, H. Rodger, A. Talbot   +9 more
wiley   +1 more source

Scaling relationships between Haversian canal‐to‐secondary osteon and midshaft femur cortical‐to‐total area in a human autopsy sample

Journal of Anatomy, EarlyView.
We report that femoral cortical thickness was strongly and negatively associated with secondary osteon porosity in an Australian autopsy sample, indicating that thicker cortices contained less porous secondary osteons. This allometric relationship held for the whole sample, males and sedentary well‐nourished individuals, but not for females or other ...
Justyna J. Miszkiewicz, Laura A. B. Wilson, Karen M. Cooke, Rita Hardiman   +3 more
wiley   +1 more source

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source

Sleep and cardiac autonomic modulation in older adults: Insights from an at‐home study with auditory deep sleep stimulation

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary The autonomic nervous system regulates cardiovascular activity during sleep, likely impacting cardiovascular health. Aging, a primary cardiovascular risk factor, is associated with cardiac autonomic disbalance and diminished sleep slow waves. Therefore, slow waves may be linked to aging, autonomic activity and cardiovascular health. However, it
Stephanie Huwiler, M. Laura Ferster, Luzius Brogli, Reto Huber, Walter Karlen, Caroline Lustenberger   +5 more
wiley   +1 more source

Whole genome sequencing of historical specimens from the world's largest fungal collection yields high‐quality assemblies

New Phytologist, EarlyView.
Summary High‐throughput molecular studies of museum specimens (museomics) have great potential in biodiversity research, but fungal historical collections have scarcely been examined, leading to no comprehensive methodological assessments. Here we present a whole genome sequencing (WGS) project conducted at the Fungarium of the Royal Botanic Gardens ...
Torda Varga, Roseina Woods, Frances Pitsillides, Rowena Hill, Alona Yu Biketova, Theo Llewellyn, Brandon J. P. Shaw, Emily Hodgson, Brigid Wong, Jasmine Le, Josepha Becker, Alexander J. Bradshaw, Seth L. E. Blake, Clementine Geeves, Quentin Levicky, Lottie Goodman, Ruben L. Mole, Sidney L. Reed, M. Carly Lin, Emily Read, Keenan Harris, Raquel Pino‐Bodas, László G. Nagy, Anna Bazzicalupo, Ester Gaya   +24 more
wiley   +1 more source

Inhibition of P‐glycoprotein using photoimmunotherapy in peritoneal metastasis mouse model

Photochemistry and Photobiology, EarlyView.
Photoimmunotherapy (PIT) using photoimmunoconjugates (PICs) can inhibit the function of the ATP‐binding cassette (ABC) transporter P‐glycoprotein (P‐gp) in a mouse model of peritoneal carcinomatosis. Sterile‐filtered PIC was administered in vivo via intraperitoneal (IP) injection 20 days after IP tumor cell implantation of P‐gp‐overexpressing NCI/ADR ...
Kaitlyn A. Moore, Brian Schnoor, Kathryn L. McNaughton, Idrisa Rahman, Benjamin D. Powers, Dana M. Roque, Huang‐Chiao Huang   +6 more
wiley   +1 more source

Timing of intrapartum transfusion among obstetric patients, stratified by admission and discharge haemoglobin, relative to anaesthesia care: A retrospective cohort study

Transfusion Medicine, EarlyView.
Abstract Background We previously validated and implemented criteria for auditing anaesthesiologists with intraoperative transfusion based on low median blood loss of the surgical procedure or absence of anaemia before transfusion. However, obstetrical cases were excluded during implementation, as the peripartum blood management protocol does not ...
Franklin Dexter, Richard H. Epstein, Unyime S. Ituk   +2 more
wiley   +1 more source

Rhesus blood group haplotype determination by nanopore sequencing and adaptive sampling enables the precise determination of complex allele combinations that could not be accurately determined by standard methods

Transfusion, EarlyView.
Abstract Background Patients with chronic transfusion needs such as those with sickle cell disease face a high risk of developing antibodies against high‐prevalence antigens in the RH blood group system, complicating transfusion therapy and potentially necessitating stem cell transplantation.
Rebekka Waldmann, Marita Führer, Annika Vogt, Dominik Nolde, Melanie Riecker, Lennart Finn Herrlich, Timo Dinse, Hubert Schrezenmeier, Christof Weinstock, David Alexander Christian Messerer   +9 more
wiley   +1 more source