Results 231 to 240 of about 374,926 (305)

Integrated Clinical Trial and Molecular Profiling Reveals Immune Drivers of Chronic Hand Eczema

open access: yesAllergy, EarlyView.
This study performed an unbiased molecular profiling of CHE patients across diverse etiologies to identify shared pathogenic drivers and evaluate the impact of IL‐4Rα blockade via dupilumab over 16 weeks. CHE shows a mixed immune signature involving type 1, 2, and 3 pathways with features of atopic dermatitis and psoriasis.
Perrine Gery   +25 more
wiley   +1 more source

Effect of Intramuscular Adrenaline on Histamine‐Induced Hypotension: A Randomised Placebo‐Controlled Pilot Trial

open access: yesAllergy, EarlyView.
Histamine infusions induce reproducible severe hypotension. Intramuscular adrenaline showed ‘supposedly therapeutic’ plasma concentrations but did not produce a sustained clinically relevant improvement in shock in the majority of recipients. These findings question adrenaline pharmacokinetic surrogate thresholds and support the need for faster and ...
Matthias Weiss‐Tessbach   +12 more
wiley   +1 more source

Smac mimetic combined with eCD4-Ig reverses latency without reducing SHIV reservoirs in rhesus macaques. [PDF]

open access: yesJ Clin Invest
Pache L   +25 more
europepmc   +1 more source

Parental Educational Attainment at Birth and Biomarkers of Male Fecundity: A Study From the Danish National Birth Cohort

open access: yesAndrology, EarlyView.
ABSTRACT Background Low parental education is associated with poorer offspring health, but its influence on male fecundity remains unclear. Objective To study the association between parental educational attainment at birth and biomarkers of male fecundity in young men and to explore whether this association is mediated by maternal smoking in pregnancy
Anne Hjorth Thomsen   +6 more
wiley   +1 more source

Optical coherence tomography and histological assessment of cutaneous vasculature and neural changes in long-term smokers: an exploratory study. [PDF]

open access: yesSci Rep
Doyle AE   +8 more
europepmc   +1 more source

Urinary alcohol and ethyl glucuronide as a screening tool for alcohol use in pregnancy: A multicenter prospective study

open access: yesActa Obstetricia et Gynecologica Scandinavica, EarlyView.
In this objective, anonymous study of 1053 women attending their first antenatal appointment, a surprisingly low percentage (0.38%) contained ethyl glucuronide (EtG), a metabolite of alcohol. These findings challenge previous studies that suggest that up to 60% of pregnant women in Ireland consume alcohol during pregnancy. Abstract Introduction Reports
Ciara A. McCormick   +10 more
wiley   +1 more source

Reinforcing the role of rural trauma laparotomy. [PDF]

open access: yesCan J Surg
Chaulk RC   +9 more
europepmc   +1 more source

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