Results 101 to 110 of about 322,811 (347)

A snapshot of ABO, RH, and JK blood group systems in modern Ireland [PDF]

, 2021
Anne Marie Browne, Anthony Kinsella, Moira Keogh, K. Morris, Stephen K. Field   +4 more
openalex   +1 more source

LDLR-Gene therapy for familial hypercholesterolaemia: Problems, progress, and perspectives [PDF]

, 2010
Coronary artery diseases (CAD) inflict a heavy economical and social burden on most populations and contribute significantly to their morbidity and mortality rates.
Al-Allaf, FA, Coutelle, C, David, A, Harbottle, R, Themis, M, Waddington, SN   +5 more
core   +3 more sources

A Systemic Selective Modified mRNA Delivery Platform for Preventing Chemotherapy‐Induced Cardiotoxicity

Advanced Science, EarlyView.
In Yoo and Mainkar et al., we present a minimally invasive, CM‐selective modRNA delivery system encapsulated in lipid nanoparticles for intravenous (IV) administration. This platform enables selective cardiac translation of therapeutic modRNA but suppresses expression in off‐target tissues, including tumors.
Jimeen Yoo, Gayatri Mainkar, Matteo Ghiringhelli, Bernardo Gindri Dos Santos, Magdalena M. Żak, Keerat Kaur, Ann Anu Kurian, Matthew Adjmi, Segev Sharon, Eftychia Markopoulou, Lucia Žigová, Daniela Hirsch, Sydney Pessin, Rachel Hanan, Juan Luis Escano Abreu, Niki Brisnovali, Nicole Dubois, Leigh Goedeke, Mengcheng Shen, Lior Zangi   +19 more
wiley   +1 more source

PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites

Advanced Science, EarlyView.
This study demonstrates that co‐inhibition of LIN28B and PARP using siLin28b/DSSP@lip‐PEG‐FA nanoparticles in combination with the PARP inhibitor BMN673 effectively suppresses the accumulation of malignant ascites associated with advanced cancers.
Yan Fang, Qian Shen, Yao Lin, Jing Zhu, Xiaolan Zhu, Rui Huang, Yijia Wu, Feiyang Shen, Qian Li, Guopei Zheng, Zhe Zhang, Qian Chu, Junhao Hu, Jianfeng Shen   +13 more
wiley   +1 more source

Blood Groups ABO and Rh System Among Paternity and Kinship Cases of Iraqi Medical Legal Directorate

, 2022
Ahmed Kadhim Mohammed, J Lefrre, P Berche, E Hosoi, T Eastlund, G Daniels, R Oriol, Abo, Hh, B Curtis, J Edwards, M Hessner, J Klein, R Aster, H Clausen, T White, K Takio, K Titani, M Stroud, E Holmes, . Hakomori, S, A Takeya, O Hosomi, M Ishiura, D Gundrajukuppam, S Vijaya, A Rajendran, J Sarella, E Bloch, M Vermeulen, E Murphy, M Matee, P Magesa, E Lyamuya, M Chester, M Olsson, Y Hashimoto, A Nakanishi, M Sasaki, T Fukushima, H Shiono, S Yip, C Yow, W Lewis, F Yamamoto, H Clausen, T White, J Marken, S Hakomori, J Lee, J Chang, D O'keefe, A Dobrovic, D Stroncek, R Konz, M Clay, J Houchins, J Mccullough, P Mollison, J Cartron, P Agre, K Boorman, B Dodd, M Bani, B Giussani, G Alemu, M Mama, T Jin, P Li, X Chen, W Hu, F Yamamoto, P Mcneill, S Hakomori, P Lutz, W Dzik, H Lee, C Barry, S Borisova, N Seto, R Zheng, A Blancher, . Palcic, M, N Avent, M Reid, G Garratty, W Dzik, P Issitt, D Lublin, M Reid, T Zelinski, P Issitt, M Crookston, M Lewis, D Anstee, Gwg Bird, G Daniels, D Anstee   +99 more
openalex   +1 more source

The vasculature and its role in the damaged and healing tendon [PDF]

, 2002
Tendon pathology has many manifestations, from spontaneous rupture to chronic tendinitis or tendinosis; the etiology and pathology of each are very different, and poorly understood. Tendon is a comparatively poorly vascularised tissue that relies heavily
Fenwick, SA, Hazleman, BL, Riley, GP
core   +2 more sources

Microenvironment Self‐Adaptive Nanoarmor to Address Adhesion‐ and Colonization‐Related Obstacles in Impaired Intestine Promote Bacteriotherapy Against Parkinson's Disease

Advanced Science, EarlyView.
A microenvironment self‐adaptive nanoarmor is developed to effectively address the adhesion‐ and colonization‐related challenges posed by multiple physiological and pathological characteristics in the intestine. L. plantarum@MPN@CS showed significant therapeutic potential in treating Parkinson's disease (PD), a model for extraintestinal disorders, as ...
Limeng Zhu, Yuyu Wu, Yingjie Chen, Xiyi Chen, Xingjie Zan, Yanlong Liu, Wujun Geng   +6 more
wiley   +1 more source

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

Identification results and distribution pattern of unexpected antibodies in 22 336 hospitalized pediatric patients

Zhongguo shuxue zazhi
[Objective] To explore the positive rate and distribution characteristics of unexpected antibodies in hospitalized children. [Methods] A total of 22 336 hospitalized pediatric patients admitted to Henan Children's Hospital from August 2018 to September ...
ZHANG Xiaopan, YANG Jiali, LI Zhihao, ZHAO Ding, TIAN Dongdong   +4 more
doaj   +1 more source

Postoperative Stress Accelerates Atherosclerosis Through Inflammatory Remodeling of the HDL Proteome and Impaired Reverse Cholesterol Transport

Advanced Science, EarlyView.
The study shows that noncardiac surgical inflammation rapidly disrupts HDL function and cholesterol efflux in mice and human patients. Impaired reverse cholesterol transport after surgery drives rapid lipid accumulation, NETosis, and apoptosis within atherosclerotic plaques.
Dominique M. Boucher, Victoria Lorant, Valerie Rochon, Abigail Carter, Cameron Stotts, My‐Anh Nguyen, Thomas Laval, Christina Emerton, Nathan Joyce, Nysa Vinayak, Marlena Scaffidi, David Cook, Katey J. Rayner, Rebecca C. Auer, Scott M. Gordon, Mireille I. Ouimet   +15 more
wiley   +1 more source