Results 141 to 150 of about 56,320 (291)

Determining the Genotype of the RH Blood Group System in Maltese Blood Donors

, 2023
Antonella Giordmaina Powney, Joseph Borg, Jesmond Debono   +2 more
openalex   +2 more sources

Piper auritum (Kunth) Fungal Endophytes: A Source of Metabolites to Inhibit the Formation of Advanced Glycation End Products

Chemistry &Biodiversity, EarlyView.
Endophytic fungi of P. auritum were evaluated for their ability to produce inhibitors of formation of advanced glycation end products (AGEs). Neopestalotiopsis sp. H2 and Diaporthe sp. H5 extracts were the most active. So, we performed their chemical profiling by untargeted and phenolics‐targeted metabolomic approaches to identify the potential ...
Lory Sthephany Rochín‐Hernández, José Antonio Guerrero‐Analco, Juan Luis Monribot‐Villanueva, Luis Bernardo Flores‐Cotera   +3 more
wiley   +1 more source

Evaluation of the distribution of ABO and Rh blood groups in geriatric patients aged ≥85 years: A retrospective single-center study. [PDF]

Medicine (Baltimore)
Merdin A, Aydin Ü.
europepmc   +1 more source

Towards the Use of Metabolic Volatiles in Breath for Determining Drug Response: Gstachamine as an Unlabeled Substrate to Measure CYP3A4 Activity

ChemMedChem, EarlyView.
A potential substrate, gstachamine, was engineered for a future CYP3A4 assay. HepG2 cell clones overexpressing CYP3A4 were used to investigate both liquid and headspace phases after incubation. A specific N‐dealkylated metabolite and butanone were detected using LC‐MS and PTR‐ToF‐MS, respectively.
Valentina Stock, Rebecca Hofer, Klaus R. Liedl, Jakob Troppmair, Thierry Langer, Hubert Gstach, Christian Dank, Sarah Kammerer, Veronika Ruzsanyi   +8 more
wiley   +1 more source

C1′‐Branched Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium Falciparum 6‐Oxopurine Phosphoribosyltransferase

ChemMedChem, EarlyView.
Novel C1'‐branched acyclic nucleoside phosphonates were synthesized. The compounds are inhibitors of Plasmodium falciparum and human 6‐oxopurine phosphoribosyltransferases with Ki values as low as 0.4 µM and 0.7 µM, respectively. A phosphonodiamidate prodrug exhibited IC50 = 4.3 µM against a drug‐sensitive strain of P.
Jan Frydrych, Dianne T. Keough, Haojun Xia, Lenka Poštová Slavětínská, Martin Dračínský, Michal Česnek, Jye Travis, Marina Chavchich, Michael Edstein, Dana Hocková, Luke W. Guddat, Zlatko Janeba   +11 more
wiley   +1 more source

Safety and Efficacy of the NMDA‐2b‐Selective Negative Allosteric Modulator BI 1569912: A Phase Ib Randomized Trial in Major Depressive Disorder

Clinical Pharmacology &Therapeutics, EarlyView.
Selective N‐methyl‐D‐aspartate receptor subunit 2b negative allosteric modulators (NR2B NAMs) are being explored as potential new treatment options for major depressive disorder (MDD). This Phase Ib, randomized, double‐blind, placebo‐controlled, parallel‐group trial was conducted in adults (N = 59) with moderate‐to‐severe MDD and insufficient response ...
Roger S. McIntyre, Gerard Sanacora, David P. Walling, Elan A. Cohen, Shishuka Malhotra, Holger Rosenbrock, Manuela Schmitz, Andreas Scholz, Sigurd D. Süssmuth, Franco De Crescenzo   +9 more
wiley   +1 more source

Comparison of demographic characteristics and haematological parameters in newborns with and without haemolytic disease due to ABO incompatibility. [PDF]

BMC Pediatr
Sahin K, Aydın T, Bilgin DD, Büyükkayhan D, Elevli M.   +4 more
europepmc   +1 more source

The pulmonary artery pulsatility index in patients with severe aortic stenosis undergoing valve replacement

ESC Heart Failure, EarlyView.
Abstract Background and aims The pulmonary artery pulsatility index (PAPi), that is, the pulmonary artery pulse pressure (PAPP) divided by the mean right atrial pressure (mRAP), is an increasingly used invasive index of right ventricular function. We sought to assess the prognostic impact of the PAPi in unselected patients with aortic stenosis (AS ...
Laura A. Rechsteiner, Lukas Weber, Philipp K. Haager, Johannes Rigger, Joannis Chronis, Peter Ammann, Roman Brenner, Martin O. Schmiady, Hans Rickli, Micha T. Maeder   +9 more
wiley   +1 more source

A simplified approach for diagnosing heart failure with preserved ejection fraction by assessing the left atrium and natriuretic peptides

European Journal of Heart Failure, EarlyView.
Applying a simplified left atrial/natriuretic peptide (LA/NP) approach by combining enlarged LA volume indexed for height2 or elevated (N‐terminal pro) B‐type natriuretic peptide [(NT‐pro)BNP], using different cut‐off values for sinus rhythm (SR) and atrial fibrillation (AF) history.
Jerremy Weerts, Arantxa Barandiarán Aizpurua, Ravi B. Patel, Arno A. van de Bovenkamp, Hesam Amin, Sandra Sanders‐van Wijk, Sanne G.J. Mourmans, Anouk Achten, M. Louis Handoko, Antoni Bayés‐Genís, Hans‐Peter Brunner‐La Rocca, Sanjiv J. Shah, Christian Knackstedt, Vanessa P.M. van Empel   +13 more
wiley   +1 more source

Impact of the ABO and Rh Blood Groups on Malaria Incidence, Recurrence, and Severity Among a Moroccan Military Contingent in the Central African Republic. [PDF]

Cureus
El Faria W, Loubadi Y, Moutmir Y, Ababou M, Hammani A, Mahtat EM, Jennane S, El Maaroufi H, Doghmi K.   +8 more
europepmc   +1 more source