Results 141 to 150 of about 427,788 (354)

Mechanochemical Strategies Applied to the Late‐Stage Modifications of Pharmaceutically Active Compounds

Angewandte Chemie International Edition, Accepted Article.
This review explores the potential of mechanochemistry in the late‐stage modification of active pharmaceutical ingredients (APIs), offering a comprehensive analysis of methods designed to transform structurally complex molecular scaffolds. By examining the scope, efficiency, and mechanistic aspects of these approaches, the review highlights protocols ...
Johanna Templ, Lars Borchardt
wiley   +1 more source

Waitlist mortality of young patients with biliary atresia: Impact of allocation policy and living donor liver transplantation

Liver Transplantation, EarlyView., 2022
Abstract Patients with biliary atresia (BA) below 2 years of age in need of a transplantation largely rely on partial grafts from deceased donors (deceased donor liver transplantation [DDLT]) or living donors (living donor liver transplantation [LDLT]).
Hedayatullah Esmati, Marieke van Rosmalen, Patrick F. van Rheenen, Marieke T. de Boer, Aad P. van den Berg, Hubert P. J. van der Doef, Michel Rayar, Ruben H.J. de Kleine, Robert J. Porte, Vincent E. de Meijer, Henkjan J. Verkade   +10 more
wiley   +1 more source

Bioimaging of sense organs and the central nervous system in extant fishes and reptiles in situ: A review

The Anatomical Record, EarlyView.
Bioimaging of the sense organs and brain of fishes and reptiles. Left panel: 3D reconstruction of the head and brain of the deep‐sea viperfish Chauliodus sloani following diceCT. Right panel: A 3D reconstruction of a 70‐day‐old embryo head of the bearded dragon Pogona vitticeps following diceCT, showing the position of the segmented brain within the ...
Shaun P. Collin, Kara E. Yopak, Jenna M. Crowe‐Riddell, Victoria Camilieri‐Asch, Caroline C. Kerr, Hope Robins, Myoung Hoon Ha, Annalise Ceddia, Travis L. Dutka, Lucille Chapuis   +9 more
wiley   +1 more source

Ingestive Behavior and Body Development of Backgrounded Heifers From Three Genotypes in the Brazilian Pantanal

Animal Research and One Health, EarlyView.
Nelore (N) and Nelore × Pantaneiro (NP) heifers exhibited similar grazing times, which were higher compared with Nelore × Angus (NA) heifers. Nelore heifers showed higher wither height and hip height values compared with NP heifers. The average values for NA heifers did not differ from the other genotypes. It was observed that chest depth, heart girth,
Maria C. E. Queiroz, Aylpy R. D. Santos, Marcelo Vedovatto, André L. J. Ferraz, Evellyn R. F. Bastianel, Marcus V. M. Oliveira, Rosana M. S. Arruda, Dalton M. Oliveira   +7 more
wiley   +1 more source

Reproductive Health Coordination Gap, Services Ad hoc: Minimum Initial Service Package (MISP) Assessment in Kenya [PDF]

, 2008
The post-election violence in Kenya in the early months of 2008 displaced more than 500,000 people. In any humanitarian crisis, certain priority reproductive health (RH) services must be put in place from the earliest stages of an emergency.

core  

Dietary supplement of sodium butyrate improves the growth performance and intestinal health by targeting Wnt/β‐catenin signaling pathway in rabbits

Animal Research and One Health, EarlyView.
Dietary supplement of sodium butyrate, may relate to regulating intestinal health and thus the growth performance and meat quality of rabbits by regulating the continuous process of promoting the periodic cycle of cecal epithelial cells. Abstract Supplementation of sodium butyrate (SB) has been proved to be beneficial for improving the growth ...
Mengke Ni, Zhitong Wang, Zhichao Li, Mengjuan Chen, Hui He, Hanfang Cai, Zhi Chen, Ming Li, Huifen Xu   +8 more
wiley   +1 more source

Oral application of L-menthol in the heat: From pleasure to performance [PDF]

, 2019
When menthol is applied to the oral cavity it presents with a familiar refreshing sensation and cooling mint flavour. This may be deemed hedonic in some individuals, but may cause irritation in others.
Barwood, Martin, Best, Russell, Gillis, Jason, Jeffries, Owen   +3 more
core  

Pharmacokinetics of betamethasone in pre‐eclampsia: An in vivo and ex vivo study

British Journal of Clinical Pharmacology, EarlyView.
Aims To enhance understanding of betamethasone and its metabolites' pharmacokinetics in pregnancy, specifically early‐onset pre‐eclampsia, through a population pharmacokinetic model. Additionally, to investigate the placental metabolism and transfer of betamethasone and its main metabolites.
Sam Schoenmakers, Letao Li, Anna C. M. Kluivers, Michelle Broekhuizen, Madhavi S. Harhangi, A. H. Jan Danser, Irwin Reiss, Karel Allegaert, Sjoerd A. A. van den Berg, Bertrand D. van Zelst, Ron H. N. van Schaik, Philip L. J. DeKoninck, Emma Ronde, Sebastiaan D. T. Sassen, Sinno H. P. Simons, Birgit C. P. Koch   +15 more
wiley   +1 more source

Morbidity after surgical management of cervical cancer in low and middle income countries: A systematic review and meta-analysis [PDF]

, 2019
Objective: To investigate morbidity for patients after the primary surgical management of cervical cancer in low and middle-income countries (LMIC). Methods: The Pubmed, Cochrane, the Cochrane Central Register of Controlled Trials, Embase, LILACS and ...
Allanson, Emma R, Bulsara, Max, Cohen, Paul, Denny, Lynette, Lee, Hong Lim, Leung, Yee, Powell, Aime   +6 more
core   +1 more source

Physics of Protein Aggregation in Normal and Accelerated Brain Aging

BioEssays, EarlyView.
Soluble monomeric proteins precipitate via nucleation into insoluble amyloids in response to age‐related exposures (e.g., microbes, nanoparticles). Persistent soluble‐to‐insoluble phase transition depletes the functional proteins. In normal aging, replacement matches loss; in accelerated aging, it does not.
Alberto J. Espay, Andrea Sturchio, Alberto Imarisio, Emily J. Hill, Brady Williamson, Kora Montemagno, Christian Hoffmann, Hugo Le Roy, Dragomir Milovanovic, Fredric P. Manfredsson   +9 more
wiley   +1 more source