Results 201 to 210 of about 186,413 (290)

Rosuvastatin PBPK Modeling: Incorporating Liver Concentrations and Effects of Ethnicity, Genetic Polymorphisms, Lactone Formation, DDI and Pregnancy

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Rosuvastatin (RSV), a potent HMG‐CoA reductase inhibitor, is widely used for the management of hyperlipidemia and prevention of cardiovascular disease. Its absorption and disposition are primarily transporter‐mediated, involving intestinal absorption by OATP2B1 and efflux by BCRP; hepatic uptake by OATP1B1, OATP1B3, OATP2B1, and NTCP; and ...
Ankit Balhara, Robert H. Weber, Jashvant D. Unadkat   +2 more
wiley   +1 more source

CRISPR-Cas9-driven antigen conversion of clinically relevant blood group systems. [PDF]

Hum Mol Genet
Boccacci Y, Dumont N, Doyon Y, Laganière J.   +3 more
europepmc   +1 more source

Population Pharmacokinetic Model of Pegbing in Healthy Subjects and Chronic Hepatitis B Patients

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Pegbing (peginterferon alpha‐2b) is a polyethylene glycol‐modified interferon α‐2b injection that has demonstrated favorable efficacy and safety profiles in the treatment of chronic hepatitis B (CHB). This study aimed to develop a population pharmacokinetic (PopPK) model of Pegbing in both healthy subjects and CHB patients and to investigate ...
Weizhe Jian, Yalin Yin, Rong Chen, Pingyao Luo, Tianyu Wang, Jianbo Gu, Zhengfang Du, Lei Cai, Tianyu Bao, Junsheng Xue, Ruoyi He, Tianyan Zhou   +11 more
wiley   +1 more source

Characterization of blood group variants in an Omani population by comparison of whole genome sequencing and serology. [PDF]

Transfusion
Haffener PE, Al-Riyami AZ, Al-Zadjali S, Al-Rawahi M, Al Hosni S, Al Marhoobi A, Al Sheriyani A, Leffler EM.   +7 more
europepmc   +1 more source

Acquired B antigen in ABO blood group system: Non-secretor group 'A1' subtype, Rh positive with auto antibodies in a patient with urinary tract infection with E. coli

, 2019
Bipin Nepal, Bikash Shrestha, Ravi Mahat, Abish Adhikari   +3 more
openalex   +2 more sources

Nanomedicine for Oral Delivery: Strategies to Overcome the Biological Barriers

Small Methods, EarlyView.
Oral delivery is a preferred administration route for many clinical applications, valued for its strong patient compliance. In this review, how nanoparticles are engineered and deployed to overcome the gastrointestinal barriers that impede clinical translation of oral delivery formulations is examined.
Luke J. Kubiatowicz, Nima Pourafzal, Audrey T. Zhu, Zhongyuan Guo, Ronnie H. Fang, Liangfang Zhang   +5 more
wiley   +1 more source

Ultrasound-Triggering Carbon Monoxide Release from Rhodium Nanoparticles for Myocardial Infarction Treatment. [PDF]

ACS Omega
Wu C, Wang X, Cai Y, Zhang J, Li H, Wang W, Yang Y, Zhang R, Cai Y, Li X, Ouyang H, Wang C.   +11 more
europepmc   +1 more source

Comparison of ABO and Rh-D Blood Group Systems between the Garo Tribal People of Mymensingh and General People of Dhaka City

, 2012
Rayhana Sultana, Zaida Rahman, Dipok Kumar Sannyal, Mohammad Abdullah Al Masud, Golam Morshed Molla, Rokeya Begum, Ruhul Amin, Sharif Shahjamal   +7 more
openalex   +2 more sources

Acute Inhalation Exposure to Ultrafine Carbon Black Alters Mitochondrial Substrate Utilization in the Heart

Environmental Toxicology, EarlyView.
ABSTRACT A majority of deaths associated with air pollution are attributed to cardiovascular and heart diseases. Carbon black that represents the carbon core of particulate matter, a major component of air pollution, has been shown to result in cardiac mitochondrial dysfunction.
William E. Mullen, Jackson E. Stewart, Rahatul Islam, Salik Hussain, Dharendra Thapa   +4 more
wiley   +1 more source

Weak D phenotype in transfusion medicine and obstetrics: Challenges and opportunities. [PDF]

World J Exp Med
Sainath PB, Ramaiyan V.
europepmc   +1 more source