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Molecular Biology of the Rh Blood Group System
Journal of Pediatric Hematology/Oncology, 2001Rh molecular biology has made many advances since the first Rh cDNA was cloned in 1990. This review summarizes the current knowledge concerning the molecular basis of Rh antigenicity, D-epitope expression, and the structures of the Rh genes and proteins.
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RH blood group system and molecular basis of Rh-deficiency
Best Practice & Research Clinical Haematology, 1999Rhesus (Rh) antigens are defined by a complex association of membrane polypeptides that are missing or severely deficient from the red cells of rare Rhnull individuals who suffer a clinical syndrome of varying severity characterized by abnormalities of the red cell shape, cation transport and membrane phospholipid organization.
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A New Antibody; Anti-Rh [27] (cE) in the Rh Blood-Group System
Vox Sanguinis, 1965RésuméUn nouvel anti‐sérum du système Rhésus, l'anti‐Rh[27] a été fabriqué par Mme Th., de type Rhésus 1,2,‐3,‐4,5,‐[27] (DCe/DCe) à la suite de transfusions de sang et de grossesses. Le sérum Th contenait également un anti‐Rh3 (E) et un anti‐S qui ont pu être éliminés facilement par absorption avec des érythrocytes Rh:‐[27], L'anti‐Rh[27] s'est ...
PatriciaA. Corcoran +3 more
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2009
Publisher Summary This chapter focuses on the Rh blood group system and this system is second to the ABO system in clinical importance because of the Rh antigens. The Rh antigens are highly immunogenic and the corresponding antibodies can result in hemolytic transfusion reactions and hemolytic disease of the fetus and newborn.
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Publisher Summary This chapter focuses on the Rh blood group system and this system is second to the ABO system in clinical importance because of the Rh antigens. The Rh antigens are highly immunogenic and the corresponding antibodies can result in hemolytic transfusion reactions and hemolytic disease of the fetus and newborn.
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The abundance and organization of polypeptides associated with antigens of the Rh blood group system
Transfusion Medicine, 1991Summary. Twelve murine monoclonal antibodies, which react with human red cells of common Rh phenotype but give weak or negative reactions with Rh null erythrocytes, were used in quantitative binding assays and competitive binding assays to investigate the abundance and organization of polypeptides involved in the expression of antigens of the Rh blood
A. E. G. Kr. von dem Borne +4 more
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Fortschritte in der Erforschung des Rh-Blutgruppensystems
Blut Zeitschrift für die Gesamte Blutforschung, 1961Es wird versucht, einen Uberblick uber die Fortschritte auf dem Gebiete der Erforschung des Rhesus-Blutgruppensystems zu geben. Die gegenwartige Entwicklung der Erkenntnisse scheint zwei einander entgegengesetzte Richtungen zu verfolgen: einerseits werden Antigene zu Komplexantigenen zusammengefast, andererseits die bisher als einheitlich aufgefasten ...
Hollaender L, Gold Er
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Isolation of a new cDNA clone encoding an Rh polypeptide associated with the Rh blood group system
Human Genetics, 1993The polymerase chain reaction (PCR) was used to amplify Rh-related cDNAs from erythroid cells cultured by the selective two-phase liquid culture system for human erythroid progenitors in peripheral blood. Direct sequencing based on PCR presents heterozygous bands.
Sadahiko Iwamoto +3 more
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Quantitative Variation in the G Antigen of the Rh Blood Group System
Vox Sanguinis, 1973Abstract. The discovery of a blood giving the reactions C‐D‐E+G+ has provided an opportunity for a study of the reactions of such cells with different anti‐C+D sera.The cells were found to adsorb antibody, even from anti‐C+D sera that showed negative reactions in direct agglutination tests.
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Model for the Rh Blood Group System Based on Discontinuous Gene Structure
Vox Sanguinis, 1981AbstractA model of the Rh blood group system is proposed which is based on discontinuous gene structure. The R29 control subregion consists of a single exon flanked by introns. Following the R29 subregion, the R1 subregion exists as seven exon structures which alternate with introns. The expression of each exon is controlled by flanking introns.
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Basic principles of the ABO and Rh blood group systems for hemapheresis practitioners
Journal of Clinical Apheresis, 1992AbstractSince 1901, more than 20 distinct blood group systems have been identified and characterized. Yet, the ABO System, the first described, remains the most clinically significant in blood transfusion and organ transplantation medicine. The ABO antigens are the only cellular antigens which consistently produce a potent, naturally occurring ...
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