Phase 1 study of sirolimus in combination with oral cyclophosphamide and topotecan in children and young adults with relapsed and refractory solid tumors. [PDF]
, 2016 PurposeTo determine the maximum tolerated dose (MTD), toxicities, and pharmacodynamics effects of sirolimus combined with oral metronomic topotecan and cyclophosphamide in a pediatric population.Materials and methodsPatients who were 1 to 30 years of age
Allen, Shelly +9 more
core +1 more source
Cancer Science, EarlyView.This study investigates genotype–phenotype correlations in Japanese families with germline TP53 pathogenic variants, collected through a nationwide prospective cancer surveillance study (JCCG LFS‐20). Among 41 families analyzed, 36 met criteria for Li–Fraumeni syndrome (LFS), and 5 were classified as attenuated LFS.
Fumito Yamazaki +14 more
wiley +1 more source
Multimodality management of soft tissue sarcomas [PDF]
, 1990 Soft tissue sarcomas are a heterogeneous group of malignant tumours arising from connective tissues of mesenchymal origin. By definition sarcomas arising from bone or cartilage are excluded though they have much in common in their behaviour as well as in
Brincat, Stephen
core
Alveolar Rhabdomyosarcoma of the foot metastasizing to the Iris: report of a rare case [PDF]
, 2016 BACKGROUND: Intraocular iris rhabdomyosarcoma is extremely rare, and in the 3 cases reported to date occurred as the primary site of tumour growth. We report a case of rhabdomyosarcoma of the foot metastasizing to the iris.
Fabian, ID +4 more
core +1 more source
Inhibition of NAD+-Dependent Metabolic Processes Induces Cellular Necrosis and Tumor Regression in Rhabdomyosarcoma Models [PDF]
, 2023 Grace B. McKay-Corkum +20 more
openalex +1 more source
Cancer Science, EarlyView.Our findings indicate that a pediatric/AYA‐specific targeted panel deployed in a hospital can deliver rapid, clinically actionable molecular insights with high diagnostic and prognostic yield. This complements larger sequencing platforms by offering speed, focused content, and easier interpretation.
Masato Kojima +8 more
wiley +1 more source
Embryonal Rhabdomyosarcoma in Mastoid and Middle Ear in a 3-Year-Old Girl: A Rare Case Report
Case Reports in Otolaryngology, 2012 Introduction. The most common sarcoma of childhood is rhabdomyosarcoma, approximately 35% of all paediatric rhabdomyosarcomas occur in the head and neck. Case Report. A 3-year-old girl referred to our clinic due to serosanguineous purulent discharge from
Saman Vegari +4 more
doaj +1 more source
MicroRNA expression profiles in pediatric dysembryoplastic neuroepithelial tumors. [PDF]
, 2016 © Springer Science+Business Media New York 2015Among noncoding RNAs, microRNAs (miRNAs) have been most extensively studied, and their biology has repeatedly been proven critical for central nervous system pathological conditions.
A Ranger +36 more
core +2 more sources
Acral Mesenchymal Spindle Cell Neoplasm With a Novel HMGA2::NCOA2 Fusion
Journal of Cutaneous Pathology, EarlyView.ABSTRACT Molecular profiling has revolutionized the field of soft tissue pathology, enhancing diagnostic precision and treatment strategies. The integration of molecular analysis and immunohistochemistry has been crucial for classifying diagnostically challenging acral mesenchymal neoplasms.
Grace Z. Armstrong +5 more
wiley +1 more source
Embryonal Rhabdomyosarcoma of Upper Lid in 15-Year-Old Patient
Case Reports in Ophthalmological Medicine, 2014 Rhabdomyosarcoma is the most common childhood primary malignant tumor of orbit. Most of patients present between the ages of 7 and 8 years. Pure eyelid rhabdomyosarcoma is a very rare tumor with only a few reported cases in the literature. We introduce a
Mohammad Sharifi
doaj +1 more source