Results 131 to 140 of about 99,358 (330)

PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator of rhabdomyosarcoma tumorigenesis

eLife, 2018
Alveolar rhabdomyosarcoma is a pediatric soft-tissue sarcoma caused by PAX3/7-FOXO1 fusion oncogenes and is characterized by impaired skeletal muscle development. We developed human PAX3-FOXO1 -driven zebrafish models of tumorigenesis and found that PAX3-
Genevieve C. Kendall, S. Watson, Lin Xu, Collette A. LaVigne, Whitney Murchison, D. Rakheja, S. Skapek, F. Tirode, O. Delattre, J. Amatruda   +9 more
semanticscholar   +1 more source

Low‐grade glial neoplasms of germ cell origin may represent maturation of embryonic‐type neuroectodermal elements

Histopathology, EarlyView.
Our results support that low grade glial tumours of germ cell origin (LGGTs) represent a phenomenon of maturation (either spontaneous or induced by therapy) of embryonic‐type neuroectoderm, being possibly equivalent to teratoma from a biological perspective.
João Lobo, Nuno Tiago Tavares, Fernanda Fernandes‐Pontes, Carmen Jerónimo, Rui Henrique, Yiying Yang, Matija Snuderl, Melissa Hruby, Muhammad T Idrees, Thomas M Ulbright, Andres M Acosta   +10 more
wiley   +1 more source

Primary alveolar rhabdomyosarcoma of the brain: a case report

Journal of Medical Case Reports
Background Primary brain rhabdomyosarcoma is a rare primary brain malignancy with few case reports. The vast majority of cases of primary brain rhabdomyosarcoma occur in pediatric patients, and immunohistochemistry can distinguish it from embryonal ...
Layal Al Mahmasani, Marwan Najjar, Roula Hourany, Abeer Tabbarah, Sara Sinno, Nathalie Chamseddine, Reine Abou Zeidane, Ghid Amhaz, Bassem Youssef, Hazem I. Assi   +9 more
doaj   +1 more source

Integrative Bayesian Analysis Identifies Rhabdomyosarcoma Disease Genes

Cell Reports, 2018
Summary: Identifying oncogenic drivers and tumor suppressors remains a challenge in many forms of cancer, including rhabdomyosarcoma. Anticipating gene expression alterations resulting from DNA copy-number variants to be particularly important, we ...
Lin Xu, Yanbin Zheng, Jing Liu, Dinesh Rakheja, Sydney Singleterry, Theodore W. Laetsch, Jack F. Shern, Javed Khan, Timothy J. Triche, Douglas S. Hawkins, James F. Amatruda, Stephen X. Skapek   +11 more
doaj   +1 more source

Accuration of Fine Needle Aspiration Biopsy in Musculoskeletal Tumour [PDF]

, 2016
Fine needle aspiration biopsy (FNAB) has been reported to be the preferable choice of biopsy for musculoskeletal tumour. While FNAB appears to have advantages to core biopsy in the aspect of simplicity and cost, the diagnostic accuracy should be the most
Dewo, P. (Punto), Lanodiyu, Z. (Zikrina), Magetsari, R. (Rahadyan), Marseno, H. (Hengkie)   +3 more
core  

Crizotinib-induced antitumour activity in human alveolar rhabdomyosarcoma cells is not solely dependent on ALK and MET inhibition [PDF]

, 2015
BACKGROUND: Rhabdomyosarcoma (RMS) is the most commonly diagnosed malignant soft tissue tumour in children and adolescents. Aberrant expression of Anaplastic Lymphoma Kinase (ALK) and MET gene has been implicated in the malignant progression of RMS ...
CAMERO, SIMONA, CECCARELLI, SIMONA, CLERICO, Anna, DOMINICI, Carlo, Losty, Paul D, Mannarino, Olga, Mcdowell, Heather P, MEGIORNI, Francesca, PAIANO, MILENA, Pizer, Barry, PIZZUTI, Antonio, Shukla, Rajeev   +11 more
core   +1 more source

Challenges of Parents While Providing Complex Medical Care at Home to Children With Cancer: A Cross‐Sectional Convergent Mixed Methods Study

Journal of Clinical Nursing, EarlyView.
ABSTRACT Aim To explore challenges parents of children with cancer encounter while providing complex medical care at home. Methods Design: Cross‐sectional convergent mixed‐methods study. Instruments: Questionnaire and open interviews that mirrored and complemented each other.
Rachel Klausner Shyman, Sveta Roberman, Gal Goldstein, Sabaa Masarwe, Amy Solnica, Rachel Yaffa Zisk‐Rony   +5 more
wiley   +1 more source

A Novel Role of Cdk9/CyclinT2 complexes in skeletal muscle and Rhabdomyosarcoma cells [PDF]

, 2010
Cyclin dependent kinase 9 (Cdk9) is a member of the cyclin dependent kinase family. The regulatory units of Cdk9 are the T family Cyclins (T1, T2) and Cyclin K1.
Marchesi, Irene
core  

Malignant phyllodes tumors display mesenchymal stem cell features and aldehyde dehydrogenase/disialoganglioside identify their tumor stem cells. [PDF]

, 2014
IntroductionAlthough breast phyllodes tumors are rare, there is no effective therapy other than surgery. Little is known about their tumor biology.
Chou, Fen-Pi, Huang, Chiun-Sheng, Hung, Jung-Tung, Liao, Guo-Shiou, Lien, Huang-Chun, Lin, Jin-Jin, Lin, Ruey-Jen, Yeh, Kun-Tu, Yu, Alice L, Yu, John   +9 more
core   +3 more sources

Rhabdomyosarcoma and Extraosseous Ewing Sarcoma

Children, 2018
Rhabdomyosarcoma (RMS) is a malignant tumor that represents the most common form of pediatric soft tissue sarcoma. It arises from mesenchymal origin and forms part of the group of small round blue cell tumors of childhood.
Juan P. Gurria, R. Dasgupta
semanticscholar   +1 more source