Results 31 to 40 of about 387,880 (260)

Epidemiology, predictors of mortality and role of prophylaxis for pneumocystitis jiroveci pneumonia among rheumatic patients: a territory-wide study

, 2021
Background: Pneumocystis jiroveci pneumonia (PJP) is an opportunistic infection affecting immunocompromised individuals. Due to its high mortality, PJP prophylaxis is commonly recommended for many immunocompromising conditions.
Li, PH, Yeung, WY, Chan, CWS, Lau, WCS, Chung, HY   +4 more
core   +1 more source

Outcomes After Concomitant Mitral and Aortic Rheumatic Valve Surgery in Young People

Proceedings
Background: Rheumatic heart disease (RHD) continues to disproportionately affect young Māori and Pacific Peoples in Aotearoa New Zealand (NZ) [...]
Hilary Hardefeldt, Steven Kiyokawa, Tom Gentles, Ajay Iyengar, Bryan Mitchelson, Dug Yeo Han, Kirsten Finucane, Nigel Wilson   +7 more
doaj   +1 more source

A Systematic Review and Meta-Analysis of Anti-Rheumatic Drugs and Pneumococcal Vaccine Immunogenicity in Inflammatory Arthritis

Vaccines, 2023
Background: Pneumococcal pneumonia is an important cause of morbidity and mortality amongst patients with inflammatory arthritis. Vaccination is recommended by the National Institute for Health and Care Excellence (NICE) but it remains unclear how ...
Deepak Nagra, Katie Bechman, Maryam Adas, Zijing Yang, Edward Alveyn, Sujith Subesinghe, Andrew Rutherford, Victoria Allen, Samir Patel, Mark D. Russell, Andrew Cope, Sam Norton, James Galloway   +12 more
doaj   +1 more source

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Review of acute rheumatic fever and rheumatic heart disease among Indigenous Australians [PDF]

, 2013
This review is intended to provide an authoritative, up-to-date account of acute rheumatic fever and rheumatic heart disease among Indigenous people.PrefaceThis review of acute rheumatic fever and rheumatic heart disease among Indigenous Australians ...
Caitlin Gray, Neil Thomson
core  

LncRNA H19 induces immune dysregulation of BMMSCs, at least partly, by inhibiting IL-2 production

Molecular Medicine, 2021
Background Systemic lupus erythematosus (SLE) is a representative systemic autoimmune disease. LncRNA H19 has been identified to participate in various biological processes in human diseases. However, the role of H19 in SLE remains unclear.
Xinpeng Chen, Xiuxia Luo, Yazhi Wei, Hualin Sun, Liping Dai, Yidou Tangzhou, Huijie Jin, Zhihua Yin   +7 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Rheumatic heart disease and acute rheumatic fever in Australia: 1996-2011 [PDF]

, 2013
Acute rheumatic fever (ARF) is rare in most developed countries, but rates among Aboriginal and Torres Strait Islander people are among the highest in the world based on available data. Rheumatic heart disease (RHD), which can be prevented by adequate

core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source