Results 11 to 20 of about 171,498 (339)

The clinical spectrum of SMA‐PME and in vitro normalization of its cellular ceramide profile

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1941-1952, December 2022., 2022
Abstract Objective The objectives of this study were to define the clinical and biochemical spectrum of spinal muscular atrophy with progressive myoclonic epilepsy (SMA‐PME) and to determine if aberrant cellular ceramide accumulation could be normalized by enzyme replacement.
Michelle M. Lee, Graeme S. V. McDowell, Darryl C. De Vivo, Daniel Friedman, Samuel F. Berkovic, Maria Spanou, Argirios Dinopoulos, Katheryn Grand, Pedro A. Sanchez‐Lara, Michelle Allen‐Sharpley, Jodi Warman‐Chardon, Alexander Solyom, Thierry Levade, Edward H. Schuchman, Steffany A. L. Bennett, David A. Dyment, Toni S. Pearson   +16 more
wiley   +1 more source

The effects of alcohol consumption and its associations with disease activity among 979 patients with inflammatory arthritis

RMD Open, 2021
Objective The role of alcohol in inflammatory disease remains debated. This study explores the relationship between alcohol and disease activity in patients with inflammatory arthritis.Methods Patients attending a rheumatology clinic between 2010 and ...
Phil Gallagher, Ursula Fearon, Sinead Maguire, Matthew Turk, Yousef Alammari, Aine Gorman, Francis Young, Tajvur Saber, Lorna Freeman, Finbar O’Shea   +9 more
doaj   +1 more source

Yoga in Rheumatic Diseases [PDF]

Current Rheumatology Reports, 2013
Yoga is a popular activity which may be well suited for some individuals with certain rheumatic disorders. Regular yoga practice can increase muscle strength and endurance, proprioception and balance, with emphasis on movement through a full range of motion to increase flexibility and mobility.
Christopher Mill, Susan J. Bartlett, Susan J. Bartlett, Susan J. Bartlett, Steffany Moonaz, Clifton O. Bingham, Sasha Bernatsky   +6 more
openaire   +5 more sources

Glycobiology of rheumatic diseases

Nature Reviews Rheumatology, 2022
Glycosylation has a profound influence on protein activity and cell biology through a variety of mechanisms, such as protein stability, receptor interactions and signal transduction. In many rheumatic diseases, a shift in protein glycosylation occurs, and is associated with inflammatory processes and disease progression.
Kissel, T., Toes, R.E.M., Huizinga, T.W.J., Wuhrer, M.   +3 more
openaire   +3 more sources

Photosensitivity in Rheumatic Diseases [PDF]

Journal of Investigative Dermatology Symposium Proceedings, 2004
There have been a number of recent advances in the genetic understanding of photosensitive rheumatic diseases, especially subacute cutaneous lupus erythematosus and dermatomyositis. These advances support the concept that increased numbers of ultraviolet light-induced apoptotic cells in skin lead to a supra-threshold concentration of antigenic peptides.
Victoria P. Werth, Victoria P. Werth, Wei Zhang, Muhammad M. Bashir   +3 more
openaire   +2 more sources

Infections in the Era of Targeted Therapies: Mapping the Road Ahead

Frontiers in Medicine, 2020
Immunosuppressive treatment strategies for autoimmune diseases have changed drastically with the development of targeted therapies. While targeted therapies have changed the way we manage immune mediated diseases, their use has been attended by a variety
Leonard H. Calabrese, Cassandra Calabrese, Tiphaine Lenfant, Tiphaine Lenfant, Tiphaine Lenfant, Elizabeth Kirchner, Vibeke Strand   +6 more
doaj   +1 more source

The Role of Myeloid-Derived Suppressor Cells in the Treatment of Pancreatic Cancer

Technology in Cancer Research & Treatment, 2022
Pancreatic cancer has the highest mortality rate of all major cancers, with a 5-year survival rate of about 10%. Early warning signs and symptoms of pancreatic cancer are vague or nonexistent, and most patients are diagnosed in Stage IV, when surgery is ...
Peng Dong MM, Yu Yan MM, Yujun Fan PhD, Hui Wang PhD, Danzhu Wu MM, Liyuan Yang MM, Junpeng Zhang PhD, Xiaoyang Yin PhD, Yajuan Lv MD, Jiandong Zhang MD, Yuzhu Hou PhD, Fengjun Liu MD, Xinshuang Yu MD   +12 more
doaj   +1 more source

Bridging the gap between science and indigenous cosmologies: Rheumatic Heart Disease Champions4Change [PDF]

Microbiology Australia, 2022
Australia has articulated a commitment to eliminate rheumatic heart disease (RHD) by 2031. Business as usual will not achieve this goal. Diverse sectors need to work together in implementing complementary strategies towards this ambitious target ...
Maida Stewart, Vicki Wade
doaj  

Treatment of rheumatoid arthritis and its outcomes in an aging society: a single-center cohort study in Japan from 2011 to 2020

Arthritis Research & Therapy, 2022
Background We conducted a single-center cohort study of rheumatoid arthritis (RA) patients from 2011 to 2020 to understand their real world treatment and outcomes, especially changes in physical function and quality of life (QOL) in elderly patients ...
Wataru Fukuda, Masatoshi Kadoya, Atsushi Omoto, Takuya Yanagida, Yu Isoda, Atsuhiko Sunaga, Hiroaki Kusuoka, Kentaro Ueno, Satoshi Morita, Masataka Kohno, Yutaka Kawahito   +10 more
doaj   +1 more source

Bioinformatics analyses of gene expression profile to identify pathogenic mechanisms for COVID-19 infection and cutaneous lupus erythematosus

Frontiers in Immunology, 2023
ObjectiveThe global mortality rates have surged due to the ongoing coronavirus disease 2019 (COVID-19), leading to a worldwide catastrophe. Increasing incidents of patients suffering from cutaneous lupus erythematosus (CLE) exacerbations after either ...
Zhenyu Gao, Zhenyu Gao, Xinchao Zhai, Xinchao Zhai, Guoqing Yan, Guoqing Yan, Yao Tian, Yao Tian, Xia Huang, Xia Huang, Qingchao Wu, Qingchao Wu, Lin Yuan, Linchong Su, Linchong Su   +14 more
doaj   +1 more source