Results 261 to 270 of about 292,383 (379)

Sugar‐sensing swodkoreceptors and swodkocrine signaling

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Sugar‐sensing swodkoreceptors that trigger swodkocrine signaling. Abstract Sugars are one of the major metabolites and are essential for nucleic acid synthesis and energy production. In addition, sugars can act as signaling molecules. To study sugar signaling at the systemic level, there is an urgent need to systematically identify sugar‐sensing ...
Savani Anbalagan
wiley   +1 more source

Biaryl Phosphates and Phosphonates as Selective Inhibitors of the Transcription Factor STAT4

open access: yesAngewandte Chemie, EarlyView.
The transcription factor STAT4 is a therapeutic target for autoimmune diseases. Here, para‐biaryl phosphates and phosphonates are presented as the first small‐molecule inhibitors of STAT4. The phosphonate Stafori‐1 selectively stabilizes STAT4 against thermal denaturation in cell lysates, and its cell‐permeable prodrug Pomstafori‐1 selectively inhibits
Nadiya Brovchenko   +7 more
wiley   +2 more sources

Improved husbandry measures to enhance reproducibility of wound healing studies in the Leprdb/db mouse

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Though the Leprdb/db mouse is a common and well‐studied model of type II diabetes mellitus, there are a few specific guidelines for its husbandry, and wound complications are common. We present a modified husbandry approach for the Leprdb/db mouse that includes increased cage size, decreased housing density, and more frequent cage changes.
May Barakat   +6 more
wiley   +1 more source

Serum Cholesterol in Rheumatic Diseases [PDF]

open access: green, 1963
Margery London   +2 more
openalex   +1 more source

Disruption of the blood–brain barrier contributes to neurobehavioral changes observed in rheumatic heart disease

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Sydenham's chorea (SC) is the neurological manifestation associated with acute rheumatic fever (ARF), triggered by a group A streptococcal (GAS) infection. Anti‐GAS antibodies cross‐reacting with tissue proteins are implicated in the development of neurological changes. In this study, using an animal model, we demonstrate that a compromised blood–brain
Rukshan Ahamed Mohamed Rafeek   +8 more
wiley   +1 more source

Risk Factors for Acute Rheumatic Disease: Exploring Factors at Individual and Collective Levels. [PDF]

open access: yesRev Soc Bras Med Trop
Mendoza RF   +11 more
europepmc   +1 more source

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