Results 271 to 280 of about 298,218 (361)

Macrophage‐Mediated Transport of Insoluble Indirubin Induces Hepatic Injury During Intestinal Inflammation

Advanced Science, EarlyView.
Plant‐derived bioactive molecules with low solubility and permeability induce hepatocyte injury, though the mechanisms driving their hepatic effects remain poorly understood. This study identifies a novel transport pathway in which poorly soluble indirubin accumulates in the liver via macrophage‐mediated uptake in Peyer's patches, exacerbating hepatic ...
Yiqi Xu, Jingchun Shi, Heung‐Lam Mok, Cheng Lyu, Junbang Chen, Chunhua Huang, Hongyan Qin, Chengyuan Lin, Hor‐Yue Tan, Zhaoxiang Bian   +9 more
wiley   +1 more source

Bidirectional Interaction Between the Brain and Bone in Traumatic Brain Injury

Advanced Science, EarlyView.
Traumatic brain injury (TBI) disrupts the blood–brain barrier and activates neuroimmune responses, causing metabolic disturbances and long‐term bone mass loss. Concurrent fractures accelerate healing and enhance osteogenesis but disrupt regulatory mechanisms, leading to altered bone dynamics and exacerbating neuroinflammation, complicating recovery ...
Wei Zhang, Jun Zou, Lingli Zhang
wiley   +1 more source

Unmasking the Hidden Threat: The Role of Left Ventricular Subendocardial Involvement in Autoimmune Rheumatic Disease. [PDF]

Clin Cardiol
Wu D, Li X, Guo T, Feng X, Li X, Wang Y, Chen W.   +6 more
europepmc   +1 more source

In Situ Valence Engineering of Copper Silicate Nanozymes with Enhanced Peroxidase‐Like Catalytic Activity for Oral Disease Detection

Advanced Science, EarlyView.
A novel copper silicate nanozyme (CSHSs‐Ar) with high peroxidase‐like catalytic activity and great catalytic specificity is well developed using a facile in situ valence‐engineered approach. The well‐developed CSHSs‐Ar nanozyme‐involved system can be utilized and employed as an efficient colorimetric sensor for the detection of volatile sulfur ...
Xiaocan Liu, Zhen Ding, Chengjing Xu, Jinming Zhang, Yufu Liu, Tianyan Chen, Shuang Dai, Xingfu Bao, Min Hu, Zhen Liu   +9 more
wiley   +1 more source

Outdoor Exercise for People with Rheumatic Disease-Study Protocol and Baseline Characteristics of the OUTdoor Physical ACtivity Cohort (OUTPAC). [PDF]

Int J Environ Res Public Health
Ahler JR, Tang LH, Poulsen DV, Skou ST, Holm PM.   +4 more
europepmc   +1 more source

Diagnosis of lumbar spinal stenosis [PDF]

, 1994
Dalgas, Marianne, Katz, Jeffrey N., Lipson, Stephen J., Stucki, Gerold   +3 more
core  

Personalized Medication for Chronic Diseases Using Multimodal Data‐Driven Chain‐of‐Decisions

Advanced Science, EarlyView.
A MDD‐CoD is proposed for personalized chronic disease medication. The framework simulates clinical chain‐of‐decisions through three linked deep learning tasks, validated on multi‐center datasets (3 hospitals, 4 diseases), demonstrating enhanced generalization and interpretability in cross‐disease applications.
Xiaoli Chu, Yiheng Ye, Siqiao Tang, Miaoru Han, Guowei Wang, Shuai Lin, Bingzhen Sun, Qingchun Huang, Yan Zhang, Xiaodong Chu, Kun Bao   +10 more
wiley   +1 more source

Risk Factors for Acute Rheumatic Disease: Exploring Factors at Individual and Collective Levels. [PDF]

Rev Soc Bras Med Trop
Mendoza RF, Mutarelli A, Mendoza BF, Barbosa JAA, Oliveira RL, Nascimento BR, Pantaleão AN, Fonseca IMG, Oliveira MAR, Pinto AS, Beaton A, Nunes MCP.   +11 more
europepmc   +1 more source

An Off‐the‐Shelf Artificial Blood Clot Hydrogel Neutralizing Multiple Proinflammatory Mediators for Pro‐Regenerative Periodontitis Treatment

Advanced Science, EarlyView.
CCS‐RSF@PRP hydrogel is engineered to structurally and functionally mimic the blood clot by integrating PPR, CCS, and RSF nanofibers through in situ activation of PRP. In a rat periodontitis model, CCS‐RSF@PRP hydrogel effectively promotes periodontal tissue repair, attributing to neutralizing the multiple proinflammatory mediators, thus rebuilding a ...
Yini Huangfu, Zhezhe Zhao, Xiang Liu, Jingrong Wang, Yufeng Zhang, Tingting Lan, Yonglan Wang, Chenxuan Wu, Ju Zhang, Pingsheng Huang, Chuangnian Zhang, Anjie Dong, Zujian Feng, Deling Kong, Weiwei Wang   +14 more
wiley   +1 more source

An Analysis of Major Adverse Cardiovascular Events, Other Adverse Events, and Efficacy in Patients with Rheumatic Disease Receiving Targeted Therapy: Experience from a Third-Level Hospital. [PDF]

J Clin Med
Rojas-Giménez M, Muñoz-Reinoso P, Arcila-Durán MD, Moreira-Navarrete V, López MM, Fernández-Alba MD, Ariza-Ariza R, Decan-Bardasz MD, Cruz BH, Toyos FJ, Mendoza DVM, Venegas JJP.   +11 more
europepmc   +1 more source