Results 131 to 140 of about 268,778 (321)

Patient and researcher perspectives on facilitating patient and public involvement in rheumatology research [PDF]

open access: yes, 2016
No abstract ...
Buckley, Christopher D.   +9 more
core   +3 more sources

HMGB1 Derived from the Pyroptotic Microenvironment Promotes Macrophage Extracellular Traps in Hirschsprung‐Associated Enterocolitis

open access: yesAdvanced Biology, EarlyView.
HMGB1 derived from the pyroptotic environment in Hirschsprung‐associated enterocolitis mediates the formation of macrophage extracellular traps through TLR4 ‐p38 MAPK/p65 NF‐kB signaling pathways. Macrophage extracellular traps induce increased ROS production and pyroptosis of colonic epithelial cells.
Rui Zhang   +6 more
wiley   +1 more source

Machine Learning-Based Analysis of ECG and PCG Signals for Rheumatic Heart Disease Detection: A Scoping Review (2015-2025) [PDF]

open access: yesarXiv
Objective: To conduct a systematic assessment of machine learning applications that utilize electrocardiogram (ECG) and heart sound data in the development of cost-effective detection tools for rheumatic heart disease (RHD) from the year 2015 to 2025, thereby supporting the World Heart Federation's "25 by 25" mortality reduction objective through the ...
arxiv  

The development of nations conditions the disease space [PDF]

open access: yesarXiv, 2019
Using the economic complexity methodology on data for disease prevalence in 195 countries during the period of 1990-2016, we propose two new metrics for quantifying the relatedness between diseases, or the `disease space' of countries. With these metrics, we analyze the geography of diseases and empirically investigate the effect of economic ...
arxiv  

Bacteria‐Derived Extracellular Vesicle as A “Trojan Horse” for Selective M1 Macrophage‐Targeting in A Multi‐Cellular Entanglement Environment

open access: yesAdvanced Functional Materials, EarlyView.
The temporary transition of macrophages from a pro‐inflammatory phenotype of macrophages (M1) to an anti‐inflammatory phenotype of macrophages (M2) is crucial for tissue repair and regeneration processes. Bacterial outer membrane vesicles (OMVs) are utilized as a “trojan horse” for specific M1 macrophage‐targeting and anti‐inflammatory drug delivery ...
Donglin Cai   +9 more
wiley   +1 more source

Increasing the Discovery Power and Confidence Levels of Disease Association Studies: A Survey [PDF]

open access: yesarXiv, 2017
The majority of common diseases are influenced by multiple genetic and environmental factors such as Cancer. Even though uncovering the main causes of disease is deemed difficult due to the complexity of gene-gene and gene-environment interactions, major research efforts aim at identifying disease risk factors, especially genetic ones.
arxiv  

Double Cross‐Linked Hydrogel for Intra‐articular Injection as Modality for Macrophages Metabolic Reprogramming and Therapy of Rheumatoid Arthritis

open access: yesAdvanced Functional Materials, EarlyView.
A hydrogel for intra‐articular injection for the treatment of rheumatoid arthritis (RA) is formulated and comprehensively studied. After administration, the hydrogel induces a metabolic reprogramming of immunometabolism of macrophages to trigger fatty acid oxidation subsequently inducing polarization of anti‐inflammatory M2 macrophages. This results in
Yutong Song   +8 more
wiley   +1 more source

Nodule Formation in Rheumatic Disease [PDF]

open access: bronze, 1946
G. D. Kersley   +2 more
openalex   +1 more source

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