Results 201 to 210 of about 10,536,235 (262)

Nanozyme‐Reinforced miR‐197‐3p Delivery Resets Metabolic and Senescence Pathways to Rejuvenate Osteoarthritic Cartilage

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a progressive and disabling joint disease driven by oxidative stress, chondrocyte senescence and extracellular matrix (ECM) degradation, yet lacks effective disease‐modifying treatments. In this study, we identified miR‐197‐3p as a previously unrecognized, cartilage‐protective miRNA significantly downregulated in both ...
Xuejie Cai, Zehui Lv, Chen Zhang, Xingdong Yang, Ruoying Wang, Yixin Bian, Jiawei Xu, Han Wang, Yingjie Wang, Long Bai, Jiacan Su, Xisheng Weng   +11 more
wiley   +1 more source

Autoantigen mRNA‐LNP Vaccination Drives Therapeutic Efficacy in Preclinical Models for Autoimmunity

Advanced Science, EarlyView.
Systemic and intramuscular delivery of autoantigen mRNA via lipid nanoparticles reprograms antigen‐presenting cells toward a mature, homeostatic state, driving antigen‐specific T cell exhaustion and providing therapeutic efficacy across autoimmune disease models.
Paulien Baeten, Karen Beets, Tessa Schalley, Janne Verreycken, Gayel Duran, Daphne Lintsen, Lisa Schuetz, Xue Zhong, Rinke Nieuwschepen, Melissa Schepers, Brecht Moonen, Jeroen Bogie, Jana Van Broeckhoven, Carlo Heirman, Jurgen Van den Heuvel, Bart Vanderborght, Ismael Varela, Roxanne Nouille, Lotte Jacobs, Jessica Filtjens, Sabah Kasmi, Elise Seynaeve, Veronica Mavrovouna, Jana De Vrieze, Michael A. Brehm, Sandra Maréchal, Sophie Janssens, Florence Lambolez, Niels Hellings, Stefaan De Koker, Bieke Broux   +30 more
wiley   +1 more source

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Sex steroids and autoimmune rheumatic diseases: state of the art

Nature Reviews Rheumatology, 2020
Maurizio Cutolo, Rainer H Straub, Cutolo Maurizio   +2 more
exaly   +2 more sources

Therapeutic glucocorticoids: mechanisms of actions in rheumatic diseases

Nature Reviews Rheumatology, 2020
Rowan Hardy, Karim Raza, Mark Cooper
exaly   +2 more sources

The IL-1 family of cytokines and receptors in rheumatic diseases

Nature Reviews Rheumatology, 2019
C. Dinarello
exaly   +2 more sources

“Dr ChatGPT”: Is it a reliable and useful source for common rheumatic diseases?

International Journal of Rheumatic Diseases, 2023
It is inevitable that artificial intelligence applications will be used as a source of information in the field of health in the near future. For this reason, we aimed to evaluate whether ChatGPT, a new Large Language Model, can be used to obtain ...
C. Uz, E. Umay
semanticscholar   +1 more source

Antimalarials in rheumatic diseases

Baillière's Clinical Rheumatology, 1990
The antimalarials hydroxychloroquine and chloroquine remain established and effective agents for the treatment of rheumatoid arthritis and systemic lupus erythematosus. Although the mechanisms of action remain uncertain, evidence is accumulating that the antirheumatic and immunological effects of the antimalarials are related to their massive ...
Tett, S, Cutler, D, Day, R
openaire   +5 more sources

Early experience of COVID‐19 vaccine‐related adverse events among adolescents and young adults with rheumatic diseases: A single‐center study

International Journal of Rheumatic Diseases, 2022
Considering the concerns regarding the coronavirus disease‐2019 (COVID‐19) vaccine safety among pediatric patients with inflammatory rheumatic diseases (IRD) due to a lack of data, an urgent need for studies evaluating safety profiles of vaccines emerged.
Fatih Haşlak, A. Gunalp, M. N. Cebi, M. Yıldız, A. Adroviç, S. Şahin, K. Barut, O. Kasapcopur   +7 more
semanticscholar   +1 more source

2023 American College of Rheumatology (ACR)/American College of Chest Physicians (CHEST) Guideline for the Screening and Monitoring of Interstitial Lung Disease in People with Systemic Autoimmune Rheumatic Diseases

Arthritis & Rheumatology
We provide evidence‐based recommendations regarding screening for interstitial lung disease (ILD) and the monitoring for ILD progression in people with systemic autoimmune rheumatic diseases (SARDs), specifically rheumatoid arthritis, systemic sclerosis,
S. Johnson, E. Bernstein, M. Bolster, Jonathan H Chung, S. Danoff, Michael D. George, Dinesh Khanna, G. Guyatt, Reza D Mirza, Rohit Aggarwal, Aberdeen Allen, S. Assassi, Lenore Buckley, Hassan A Chami, D. Corwin, P. Dellaripa, R. Domsic, T. Doyle, C. Falardeau, Tracy M. Frech, Fiona K Gibbons, M. Hinchcliff, Cheilonda R Johnson, J. Kanne, John S. Kim, Sian Yik Lim, S. Matson, Zsuzsanna H. McMahan, Samantha J Merck, Kiana Nesbitt, M. Scholand, L. Shapiro, Christine D Sharkey, Ross Summer, John Varga, Anil Warrier, Sandeep K. Agarwal, D.E. Antin-Ozerkis, B. Bemiss, Vaidehi R Chowdhary, Jane E Dematte D'Amico, R. Hallowell, Alicia M Hinze, Patil A Injean, Nikhil Jiwrajka, Elena K. Joerns, Joyce S Lee, A. Makol, Gregory C. McDermott, J. Natalini, J. Oldham, D. Saygin, K. Lakin, Namrata Singh, J. Solomon, Jeffrey A. Sparks, M. Turgunbaev, Samera Vaseer, Amy S. Turner, Stacey Uhl, I. Ivlev   +60 more
semanticscholar   +1 more source

The Rheumatic Diseases in Childhood

Postgraduate Medicine, 1969
In general the laboratory is only moderately helpful in identifying rheumatic diseases in children. Diagnosis depends on careful attention to clinical detail and sometimes on protracted observation. Direct cure is usually not possible but treatment based on correct diagnosis can make the difference between life and death or between severe disability ...
V, Hanson, H, Kornreich
openaire   +2 more sources