Results 291 to 300 of about 392,718 (341)

CRISPLD2 Attenuates Intervertebral Disc Degeneration by Suppressing Oxidative Stress‐Induced Ferroptosis through the miR‐548I‐IL17A Axis

Advanced Science, EarlyView.
This study identifies CRISPLD2 as a key protector against IVDD. By regulating ferroptosis through the CRISPLD2–miR‐548I–IL17A axis, CRISPLD2 maintains NPCs homeostasis and reduces oxidative stress. Restoring CRISPLD2 expression effectively alleviates disc degeneration and highlights a promising therapeutic strategy for discogenic low back pain ...
Yangyang Shi, Fudong Li, Tianyi Zhao, Kaiqiang Sun, Danying Zhang, Chen Yan, Ximing Xu, Jingchuang Sun, Xulin Hu, Xin Yong, Jiangang Shi, Yuan Wang   +11 more
wiley   +1 more source

Causality between rheumatic diseases and iron-deficiency anemia: A 2-sample, 2-step mediation Mendelian randomization investigation. [PDF]

Medicine (Baltimore)
Huang W, Lv L, Zhang Y, Jin T, Cheng Y, Geng L, Feng X.   +6 more
europepmc   +1 more source

Health at Older Ages: The Causes and Consequences of Declining Disability among the Elderly [PDF]

Dora L. Costa
core  

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Effectiveness and Safety of Recombinant Zoster Vaccine in Rheumatic Diseases: Real-World Evidence from a Single-Centre Italian Cohort. [PDF]

Vaccines (Basel)
Valentini S, Sota J, Fineschi I, Conticini E, Garcia-Gonzalez E, D'Ignazio E, Bardelli M, Gentileschi S, Fabbroni M, Bellisai F, Falsetti P, Selvi E, Cantarini L, Frediani B, Baldi C.   +14 more
europepmc   +1 more source

Editorial: Pulmonary involvement in systemic autoimmune rheumatic diseases (SARDs): from diagnostic tools to therapeutic strategies. [PDF]

Front Med (Lausanne)
Vasarmidi E, Otaola M, Juge PA.
europepmc   +1 more source

Current Approaches to the Management of Rheumatic Diseases in Pregnancy: Risk Stratification, Therapeutic Advances, and Maternal-Fetal Outcomes. [PDF]

J Pers Med
Giannakaki AG, Giannakaki MN, Bothou A, Nikolettos K, Machairiotis N, Pappa KI, Tsikouras P.   +6 more
europepmc   +1 more source

Iron metabolism in rheumatic diseases. [PDF]

J Transl Autoimmun
Givian A, Azizan A, Jamshidi A, Mahmoudi M, Farhadi E.   +4 more
europepmc   +1 more source

Healthcare Interventions in the Management of Rheumatic Diseases: A Narrative Analysis of Effectiveness and Emerging Strategies. [PDF]

Healthcare (Basel)
Verga Răuță GI, Baltă AAȘ, Ciortea DA, Petrea Cliveți CL, Șerban Grădinaru M, Matei MN, Gurău G, Șuța VC, Voinescu DC.   +8 more
europepmc   +1 more source