Results 41 to 50 of about 6,012,951 (335)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Active surveillance for rheumatic heart disease in endemic regions: a systematic review and meta-analysis of prevalence among children and adolescents

The Lancet Global Health, 2014
Background: Rheumatic heart disease accounts for up to 250 000 premature deaths every year worldwide and can be regarded as a physical manifestation of poverty and social inequality.
Martina Rothenbühler, MSc, Crochan J O'Sullivan, MD, Stefan Stortecky, MD, Giulio G Stefanini, MD, Ernest Spitzer, MD, Janne Estill, PhD, Nikesh R Shrestha, MD, Olivia Keiser, PhD, Prof. Peter Jüni, MD, Dr. Thomas Pilgrim, MD   +9 more
doaj   +1 more source

Improvement of Rheumatic Valvular Heart Disease in Patients Undergoing Prolonged Antibiotic Prophylaxis

Frontiers in Cardiovascular Medicine, 2021
Secondary prophylaxis of rheumatic heart diseases is efficient in reducing disease recurrence, heart damage, and cardiac impairment. We aimed to monitor the clinical evolution of a large Brazilian cohort of rheumatic patients under prolonged secondary ...
Renato Pedro de Almeida Torres, Rômulo Francisco de Almeida Torres, Gabrielle de Crombrugghe, Scarllet Palacin Moraes da Silva, Sarah Leticia Veroneze Cordeiro, Karine Alessandra Bosi, Pierre R. Smeesters, Pierre R. Smeesters, Pierre R. Smeesters, Pierre R. Smeesters, Rosângela Stadnick Lauth de Almeida Torres, Rosângela Stadnick Lauth de Almeida Torres   +11 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

The kidney in rheumatic heart disease [PDF]

Journal of Clinical Pathology, 1962
Histological evidence of glomerulonephritis is reported in 95 (38·6%) of a series of 246 necropsies with concomitant rheumatic carditis. The details of these findings are given and their significance is discussed.
openaire   +2 more sources

Rheumatic heart disease and acute rheumatic fever in Australia: 1996-2011 [PDF]

, 2013
Acute rheumatic fever (ARF) is rare in most developed countries, but rates among Aboriginal and Torres Strait Islander people are among the highest in the world based on available data. Rheumatic heart disease (RHD), which can be prevented by adequate

core  

Vascular Disease, Non‐Steroidal Anti‐Inflammatory Drugs and Risk of Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives A history of vascular disease has been shown to be associated with an increased risk of Parkinson's disease, but this may be due to reverse causation. In addition, non‐steroidal anti‐inflammatory drugs are thought to reduce Parkinson's disease risk, but evidence is inconsistent and confounding by prior vascular disease is possible ...
Clare Wotton, Carol Hermon, Sarah Floud, Gillian Reeves, Isobel Barnes   +4 more
wiley   +1 more source

Formal and Informal Social Care in People With Rheumatic and Musculoskeletal Diseases: A Cross‐Sectional Multicenter Survey

Arthritis Care &Research, EarlyView.
Objective Rheumatic and musculoskeletal diseases (RMDs) are leading causes of physical disability, necessitating support with activities of daily living. This study describes social care received by patients with RMDs in two disparate regions of England: Salford (urban) and Norfolk (rural).
Mehreen Somro, Karen Durrant, William G. Dixon, John McBeth, Alex MacGregor, Max Yates, Jenny H. Humphreys   +6 more
wiley   +1 more source

Heart Transplantation in Endstage Rheumatic Heart Disease - Experience of an Endemic Area

, 2017
Background: Rheumatic heart disease (RHD) remains a significant cause of cardiovascular disease in developing countries. The nonsuppurative cardiovascular sequel of group A streptococcal infection is sustained inflammatory and immune reactions toward the
Chi, Nai-Hsin;Chou, Nai-Kuan;Yu, Ya-Hui;Yu, Hsi-Yu;Wu, I-Hui;Chen, Yih-Sharng;Huang, Shu-Chien;Ko, Wen-Je;Wang, Shoei-Shen, 紀乃新;虞希禹;吳毅暉;陳益祥;周迺寬;黃書健;柯文哲;王水深   +1 more
core   +1 more source

Building a Framework for Sexual and Reproductive Health Care in the Rheumatology Context: Content and Approaches

Arthritis Care &Research, EarlyView.
People with systemic autoimmune and rheumatic diseases (SARDs) are at higher risk than the general population of experiencing adverse pregnancy and perinatal outcomes such as preeclampsia, intrauterine growth restriction, and maternal and/or fetal death.
Mehret Birru Talabi, Sonya Borrero
wiley   +1 more source