Results 301 to 310 of about 1,123,888 (385)

New Horizons for Multiple Sclerosis Therapy: 2025 and Beyond

Annals of Neurology, EarlyView.
The advances achieved against multiple sclerosis (MS) represent one of the great success stories of modern molecular medicine. The development of therapies with increasing selectivity and safety, guided by gains in understanding the fundamental immunology, neurobiology, genetics, and triggers of this disease, have broadened the traditional focus on ...
Joseph J. Sabatino Jr., Bruce A. C. Cree, Stephen L. Hauser   +2 more
wiley   +1 more source

Clonal hematopoiesis is associated with distinct rheumatoid arthritis phenotypes. [PDF]

Sci Adv
Hiitola E, Korhonen J, Kokkonen H, Koskela J, Kankainen M, Alakuijala M, Liu A, Lundgren S, Häppölä P, Almusa H, Ellonen P, Savola P, Kelkka T, Leirisalo-Repo M, Koivuniemi R, Peltomaa R, Pirilä L, Isomäki P, Kauppi M, Kaipiainen-Seppänen O, Starskaia I, Virtanen AT, Lahesmaa R, Silvennoinen O, FinnGen, Genovese G, Ganna A, Rantapää-Dahlqvist S, Mustjoki S, Myllymäki M.   +29 more
europepmc   +1 more source

Potential Application of a Water‐Soluble Fullerene C60 Decorated with Diethylene Glycol in Treatment of Osteoarthritis

Advanced NanoBiomed Research, EarlyView.
A new ethoxyethanol derivative of iminofullerene, F2, is synthesized and labeled with 99mTc to produce 99mTc‐F2. In vitro, compound F2 inhibits the activation of primary mouse bone marrow‐derived macrophages stimulated with lipopolysaccharide. Moreover, 99mTc‐F2 is selectively enriched in the injured joints of mice. Inflammatory macrophages play a role
Rui He, Alyssa Costello, Yanjie Liu, Weicheng Wang, Zhichang Zhang, Quanjun Cui, Xinlin Yang   +6 more
wiley   +1 more source

Functional Synovium‐Based 3D Models in the Context of Human Disease and Inflammation

Advanced NanoBiomed Research, EarlyView.
The synovium is key to joint function but is often affected by diseases like rheumatoid arthritis. Finding better treatments is challenging because current lab models do not fully mimic real tissues. New 3D technologies, like bioprinting, offer better methods to study these diseases, improve drug testing, and develop personalized treatments, bringing ...
Amelia Heslington, Catharien M. U. Hilkens, Ana Marina Ferreira, Priscila Melo   +3 more
wiley   +1 more source

Vagotomy and the incidence of rheumatoid arthritis and osteoarthritis: a Danish register-based study. [PDF]

Arthritis Res Ther
Baker MC, Nagy D, Tamang S, Horváth-Puhó E, Sørensen HT.   +4 more
europepmc   +1 more source

Guidelines for the management of the foot affected by rheumatoid arthritis [PDF]

, 2010
Bowen, C, Dagg, A, Davies, S, Graham, A, Longrigg, K, Lyons, C, Williams, AE   +6 more
core  

Metabolic Stress Expands Polyfunctional, Proinflammatory Th17 Cells in Patients With Psoriatic Arthritis for Whom There is Interleukin‐23–Independent Interleukin‐17 Production

Arthritis &Rheumatology, EarlyView.
Objective Genetic associations and blockade of the interleukin (IL)‐23/IL‐17 axis with monoclonal antibodies support a role for this pathway in patients with psoriatic arthritis (PsA). This study examines the requirement of IL‐23 for IL‐17 production and the role of the metabolic microenvironment in the expansion of Th17‐derived cells in patients with ...
Carmel B. Stober, Louise Ellis, Jane C. Goodall, Marc Veldhoen, J. S. Hill Gaston   +4 more
wiley   +1 more source

Late-onset rheumatoid arthritis: clinical features, diagnostic challenges, and treatment approaches. [PDF]

Rheumatol Int
Zimba O, Baimukhamedov C, Kocyigit BF.
europepmc   +1 more source

An Immunosenescent CD8+ T Cell Subset in Patients with Axial Spondyloarthritis and Psoriatic Arthritis Links Spontaneous Motility to Telomere Shortening and Dysfunction

Arthritis &Rheumatology, EarlyView.
Objective A pathogenetic role of CD8+ T lymphocytes in radiographic axial spondyloarthritis (r‐axSpA) and other spondyloarthritis (SpA) is sustained by genome‐wide association studies and by the expansion of public T cell clonotypes in the target tissues.
Giorgia Paldino, Valentina Tedeschi, Valentina Proganò, Erica Salvati, Valerio Licursi, Eleonora Vertecchi, Alexandru L. Bivolaru, Emanuele Molteni, Rossana Scrivo, Mattia Congia, Alberto Cauli, Rosalba Caccavale, Marino Paroli, Martina Kunkl, Loretta Tuosto, Rosa Sorrentino, Maria Teresa Fiorillo   +16 more
wiley   +1 more source

Towards better personalized care in rheumatoid arthritis. [PDF]

Rheumatology (Oxford)
Taylor PC.
europepmc   +1 more source