Results 211 to 220 of about 696,455 (247)

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Tofacitinib Regulates β‐Catenin Nuclear Translocation to Inhibit FLS Migration and Alleviate Clinical Symptoms of RA

iNew Medicine, EarlyView.
ABSTRACT Objective Tofacitinib is a Janus kinase (JAK) inhibitor approved for the treatment of moderate‐to‐severe rheumatoid arthritis (RA). However, its synovium‐related molecular mechanisms, particularly its regulatory effect on fibroblast‐like synoviocyte (FLS) migration, remain incompletely understood.
Shuqi Fang, Tianjing Zhang, Ling Hu, Ruijin Liu, Leyi Jia, Menglin Bai, Jiale Dong, Yuchen Zhao, Han Wang, Lei Zhang, Tao Li, Youcai Deng, Xianzheng Zhang, Lingling Zhang   +13 more
wiley   +1 more source

Zero Time‐to‐Echo Imaging of the Hand and Wrist in Rheumatoid Arthritis Patients

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Zero time‐to‐echo (ZTE) imaging allows for signal acquisition from tissues with extremely short T2* relaxation times, enabling the generation of computed tomography (CT)‐like images through gray‐scale inversion. Purpose To assess the usefulness of adding ZTE imaging to conventional MRI for the detection of hand and wrist bone ...
Jun Tsukamoto, Akitaka Fujisaki, Yoshiko Hayashida, Seiichi Murakami, Atsushi Nagayasu, Yasuyuki Todoroki, Shingo Nakayamada, Yoshiya Tanaka, Takatoshi Aoki   +8 more
wiley   +1 more source

Depressive Symptoms, sleep Disturbance, and Cardiometabolic Multimorbidity Among Adults With Arthritis: A Cross‐Sectional Analysis of NHANES 2013–2020

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT While the association between depressive symptoms and cardiometabolic disease is well established, the relationships among depressive symptoms, sleep disturbance, and cardiometabolic multimorbidity (CMM) in adults with arthritis remain insufficiently understood.
Lu‐Niao Ma, Jing‐Cheng Jiang, Jun‐Jie Lan, Yang‐Yang Chen, Hui‐Min Zhang, Yao Zeng, Xu‐Hui Huang, Xiao‐Na Tang   +7 more
wiley   +1 more source

Disulfidptosis‐ and Ferroptosis‐Related Gene Signatures in Rheumatoid Arthritis: Association Analysis and Diagnostic Model Construction

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and progressive joint damage. Although ferroptosis has been implicated in RA progression, the role of disulfidptosis and its interaction with ferroptosis remains unclear.
Ting‐Ting Wang, Dong‐Mei Wang, Xue Li, Yuan‐Li Wei, Ping‐Dan Liu, Shi‐Lin Li, Si‐Ying Xiong, Cai‐Zhen Liu, Fan‐Xin Zeng, Jian‐Hong Wu, Lin Tang   +10 more
wiley   +1 more source

Remote Monitoring for Rheumatoid Arthritis Flare During Drug Tapering: Protocol for a Prospective Observational Cohort Study. [PDF]

JMIR Res Protoc
Sarvestan J, Shahmandi M, Elndari N, Wason JM, Del Din S, Baker KF.   +5 more
europepmc   +1 more source

Managing the meniscus part I—Anatomy, biomechanics, and treatment strategies for the atraumatic meniscus tear

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose The purpose of this article is to serve as the first of a two‐part review on the meniscus; in this review, we will establish the background on anatomy and pathogenesis of the meniscus, as well as the effect of the meniscus on native knee kinematics and function.
Ehab M. Nazzal, Jonathan D. Hughes, Armin Runer, Matthew P. Kolevar, Jorge Chahla, Robert G. Marx, James J. Irrgang, Roman Seil, Berte Bøe, David Parker, Ryosuke Kuroda, Eric H. Senorski, Sachin Tapasvi, Volker Musahl   +13 more
wiley   +1 more source

Systemic and local autoantibody responses to extracellular matrix proteins define inflammatory phenotypes across arthropathies. [PDF]

Rheumatology (Oxford)
Krawetz RJ, Matyas M, Abubacker S, Veeramreddy DN, Jay GD, Schmeling H, Schmidt TA, Fritzler MJ.   +7 more
europepmc   +1 more source

Serum asprosin levels in patients with rheumatoid arthritis: An exploratory cross-sectional study. [PDF]

Medicine (Baltimore)
Zontul S, Kaya Z, Aydoğdu MS, İnanç E, Çetin M, Yolbaş S, Arslan AK, Uçar C.   +7 more
europepmc   +1 more source

Plant-Derived Heterocyclic Compounds: A Promising Review on Natural Remedies for Rheumatoid Arthritis Management and Their Mechanistic Insights in Inflammation and Joint Protection. [PDF]

Basic Clin Pharmacol Toxicol
Dai J, Xia X, Hu X, Kanagaraj T, Rajalakshmi K, Deshpande M, Kiruthiga N, Zhu D, Fan Y.   +8 more
europepmc   +1 more source