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The term rheumatoid factors has been applied to a class of closely related proteins that are responsible for a variety of serological reactions currently employed for the diagnosis of rheumatoid arthritis. A marked intensification of interest in these factors has developed during the past two years, primarily because there is an intuitive feeling that ...
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Specificity of a Rheumatoid Factor
Acta Rheumatologica Scandinavica, 1961SummaryStudies on the gamma globulin (Gm) groups have shown that a rheumatoid factor may have a remarkable specificity concerning its ability to react with gamma globulin from different individuals. The »specific» hemagglutinating substances of the Gm system and the substance responsible for the positive Waaler-Rose test are probably closely related ...
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Isolating the Rheumatoid Factor
Acta Rheumatologica Scandinavica, 1959SummaryA large number of tests have been tried with a view to making differential diagnoses in collagen diseases. The hemagglutination test has proved to be the most valuable.By using the methods of fractionating in cold, zone-electrophoresis, chromatography with a cation exchanger and ultracentrifuging it has been found possible to purify in a high ...
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The Utility of the Rheumatoid Factor
Archives of Internal Medicine, 1993The conclusions made by Shmerling and Delbanco 1 regarding the utility of rheumatoid factor (RF) in the diagnosis of rheumatoid arthritis (RA) came as a bit of a surprise, seemingly reversing conventional thinking. Although we can agree, based on their data, that RF is, at times, ordered inappropriately (ie, in the absence of joint complaints), we find
Kim Cusato, Tom Bush
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Current Opinion in Rheumatology, 2004
Initial studies of the pathogenesis of rheumatoid arthritis focused on the role of rheumatoid factor and immune complex-associated vasculitis and synovitis. Subsequent work has delineated T cell responses, the role of cytokines, chemokines, and the aggressive nature of rheumatoid synovitis.
Karl Egerer+3 more
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Initial studies of the pathogenesis of rheumatoid arthritis focused on the role of rheumatoid factor and immune complex-associated vasculitis and synovitis. Subsequent work has delineated T cell responses, the role of cytokines, chemokines, and the aggressive nature of rheumatoid synovitis.
Karl Egerer+3 more
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Journal of Clinical Microbiology, 1985
Immunoglobulin M (IgM) antibodies directed against IgG antibodies (rheumatoid factor [RF]) are known to occur often in patients with syphilis and to interfere with serological tests measuring specific antibodies of the IgM class. In this study we examined the occurrence and specificity of the RF and demonstrated a simple method to detect and eliminate ...
Carol E. Farshy+3 more
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Immunoglobulin M (IgM) antibodies directed against IgG antibodies (rheumatoid factor [RF]) are known to occur often in patients with syphilis and to interfere with serological tests measuring specific antibodies of the IgM class. In this study we examined the occurrence and specificity of the RF and demonstrated a simple method to detect and eliminate ...
Carol E. Farshy+3 more
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Pseudoglobulin Rheumatoid Factors
The Journal of Immunology, 1965Summary Although the rheumatoid factors (RF) are believed to be relatively insoluble in dilute salt solutions, considerable RF activity in pseudoglobulin fractions was encountered on examination of certain sera of persons having rheumatoid arthritis.
R, HEIMER, C J, NOSENZO
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Transactions of the Royal Society of Tropical Medicine and Hygiene, 1992
We have studied the distribution of rheumatoid factor isotypes amongst patients with loiasis with and without accompanying glomerulonephritis to determine the possible role of rheumatoid factor antiglobulins in this disease. Our findings indicate an increase in both immunoglobulin (Ig) G and IgM rheumatoid factor isotypes in patients with filariasis ...
B. L. Hazleman+4 more
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We have studied the distribution of rheumatoid factor isotypes amongst patients with loiasis with and without accompanying glomerulonephritis to determine the possible role of rheumatoid factor antiglobulins in this disease. Our findings indicate an increase in both immunoglobulin (Ig) G and IgM rheumatoid factor isotypes in patients with filariasis ...
B. L. Hazleman+4 more
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2007
Rheumatoid factors (RFs) are autoantibodies with specificity against constant regions of the heavy chain in the IgG Fc fragment. RFs are detected in several systemic autoimmune conditions and in infectious diseases and can be present in healthy subjects.
Pier Luigi Meroni, Valentina De Angelis
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Rheumatoid factors (RFs) are autoantibodies with specificity against constant regions of the heavy chain in the IgG Fc fragment. RFs are detected in several systemic autoimmune conditions and in infectious diseases and can be present in healthy subjects.
Pier Luigi Meroni, Valentina De Angelis
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Determination of Rheumatoid Factors by ELISA
2018IgM and IgA autoantibodies binding to IgG are called rheumatoid factors (RFs) and occur with high frequency in rheumatoid arthritis (RA) and with lower frequency in other autoimmune diseases. RFs have diagnostic and prognostic value in RA, but they also have a high potential to cause false positive reactions in other immunoassays, especially sandwich ...
Trier, Nicole Hartwig, Houen, Gunnar
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