Results 281 to 290 of about 384,620 (341)

Mesencephalic Astrocyte‐Derived Neurotrophic Factor Binds BAX to Preserve Mitochondrial Homeostasis and Energy Metabolism for Relieving Myocardial Hypertrophy

open access: yesAdvanced Science, EarlyView.
MANF in cardiomyocytes interacts with BAX to impede BAX mitochondrial translocation and cytochrome c release, further stabilizing mitochondrial structure and energy supply to relieve myocardial apoptosis and hypertrophy, which indicates MANF as a novel cardioprotective factor to have a promising clinical application for myocardial hypertrophy ...
Dong Wang   +13 more
wiley   +1 more source

CellPhenoX: An Explainable Machine Learning Method for Identifying Cell Phenotypes To Predict Clinical Outcomes from Single‐Cell Multi‐Omics

open access: yesAdvanced Science, EarlyView.
CellPhenoX is an explainable machine learning framework that identifies cell‐specific phenotypes and interaction effects from single‐cell omics data. By leveraging interpretable models, it enables robust discovery of cell‐level phenotypes that contribute to clinical outcomes.
Jade Young   +4 more
wiley   +1 more source

Rheumatoid factor positive plasma and humoral cytotoxicity to malignant melanoma

open access: bronze, 1978
Jeremiah J. Twomey   +4 more
openalex   +1 more source

Personalized Medication for Chronic Diseases Using Multimodal Data‐Driven Chain‐of‐Decisions

open access: yesAdvanced Science, EarlyView.
A MDD‐CoD is proposed for personalized chronic disease medication. The framework simulates clinical chain‐of‐decisions through three linked deep learning tasks, validated on multi‐center datasets (3 hospitals, 4 diseases), demonstrating enhanced generalization and interpretability in cross‐disease applications.
Xiaoli Chu   +10 more
wiley   +1 more source

Association of rheumatoid factor, anti-citrullinated protein antibodies and shared epitope with clinical response to initial treatment in patients with early rheumatoid arthritis: data from a randomised controlled trial. [PDF]

open access: yesAnn Rheum Dis
Lend K   +20 more
europepmc   +1 more source

AGAPIR: A Novel PIWI‐Interacting RNA Enhancing Post‐Decompression Angiogenesis in Degenerative Cervical Myelopathy

open access: yesAdvanced Science, EarlyView.
The restoration of blood flow following surgical decompression for degenerative cervical myelopathy (DCM) significantly contributes to the amelioration of neurological deficits. This study identifies AGAPIR, an angiogenesis‐associated PIWI‐interacting RNA, enhances angiogenesis and motor function recovery post‐spinal cord decompression in a mouse model
Yongheng Xie   +8 more
wiley   +1 more source

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