Results 71 to 80 of about 4,504,355 (205)

Early synovial regulatory T cell engagement in posttraumatic osteoarthritis

Arthritis &Rheumatology, Accepted Article.
Objective Posttraumatic osteoarthritis (PTOA) develops despite restoration of joint biomechanics, suggesting that early post‐injury biological processes within the synovium shape disease trajectories. We investigated whether synovial regulatory T (Treg) cells are engaged during the early phase following joint injury and whether experimental enrichment ...
Xueyou Zhang, Mingde Cao, Jianting Li, Bruma Sai‐Chuen Fu, Michael Tim‐Yun Ong, Patrick Shu‐Hang Yung   +5 more
wiley   +1 more source

Persistence of a rheumatoid factor (RF)-producing B cell clone with a somatically mutated Igκ chain in a patient with rheumatoid arthritis

Clinical and Experimental Immunology, 1994
SUMMARYThe VκIV gene encoding the light chain of an IgA RF has been shown to have undergone 31 somatic mutations compared with the single existing VκIV germ-line gene. We now show the persistence of the rearranged and mutated DNA coding for this RF over a period of 5 years in the peripheral blood lymphocytes (PBL) of the patient with rheumatoid ...
A, Schrauder, A, Gause, W, Jung, R, Mierau, M, Pfreundschuh   +4 more
openaire   +3 more sources

Shared and Distinguishing Features of Late‐Onset Rheumatic Diseases Fulfilling Polymyalgia Rheumatica Classification Criteria

Arthritis &Rheumatology, Accepted Article.
‐
Kerem Abacar, Ala Altaie, Andrew Barr, Sarah L. Mackie, Kulveer Mankia, Dennis McGonagle   +5 more
wiley   +1 more source

Association between the HLA-DRB1 with the disease activity parameters among Egyptian RA patients [PDF]

Arcades of Medicine
Background: Rheumatoid factor (RF) and anti-cyclic citrullinated peptide (ACCP), both indicators of seropositivity and closely linked to rheumatoid arthritis (RA), have been correlated with the human leukocyte antigen (HLA), +DRB1 allele.
Ali Abd El-Razik, Mostafa ElNakib, Dahlia Hussein, Fatma Badr   +3 more
doaj   +1 more source

COMPARISON OF RHEUMATOID FACTOR (RF) AND ANTI CYCLIC CITRULLINATED PEPTIDE (ANTI -CCP) ANTIBODIES IN EARLY DIAGNOSIS OF RHEUMATOID ARTHRITIS.

INDIAN JOURNAL OF APPLIED RESEARCH, 2020
Background: Rheumatoid arthritis (RA) is an autoimmune disease associated with chronic inflammation of joints causing deformities and functional impairment. Rheumatoid factor (RF) is an autoantibody specific for the Fc portion of human IgG. RF has low specificity as high false positive results are common in the general population.
Reshmy GS, Mrudula EV, Sumitha Prabhu PS, Ashika MS, Sumithra N Unni, Sajitha Krishnan P   +5 more
openaire   +1 more source

MDL‐800‐induced SIRT6 activation decreases age‐associated osteoarthritis in mice

Arthritis &Rheumatology, Accepted Article.
Objective SIRT6 is a nuclear‐localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of a small molecule activator of SIRT6, MDL‐800, decreases the severity of age‐associated osteoarthritis (OA) in mice.
Matheus Moreira Perez, Pranay Ramteke, Bahiyah Watson, Owen Haslam, Eirene Choi, Susan Chubinskaya, Mandy J. Peffers, William R. Davis, Jacqueline Shine, Brian O. Diekman, Richard F. Loeser, Theresa A. Freeman, Makarand V. Risbud, John A. Collins   +13 more
wiley   +1 more source

Biologic treatments in rheumatoid arthritis and juvenile idiopathic arthritis [PDF]

, 2006
A number of biological approaches to the management of inflammtory arthropathies have been explored. These include the development of IL-1 receptor antagonists and TNF antagonists. Four biological agents are currently marketed in Europe.
Borg, Andrew A.
core  

American College of Rheumatology/European League Against Rheumatism Provisional Definition of Remission in Rheumatoid Arthritis for Clinical Trials [PDF]

, 2011
Remission in rheumatoid arthritis (RA) is an increasingly attainable goal, but there is no widely used definition of remission that is stringent but achievable and could be applied uniformly as an outcome measure in clinical trials.
Matucci-Cerinic, M., Richards, P., American College of Rheumatology,, Robert Landewé, Pamela Richards, Alan Tyndall, Wit, M. de, Siegel, Jeffrey N., John Kirwan, Gillian Hawker, Daniel Aletaha, Simon, L.S., Dougados, Maxime, White, Barbara, Montie, Pamela, Kvien, T.K., Andrew Brown, Funovits, J., Combe, Bernard, Aletaha, Daniel, Tuyl, H.D. van, Tuulikki Sokka, Brooks, Peter, Brown, Andrew, Kirwan, J, Josef S. Smolen, Bathon, J., Suzan Verstappen, Choi, Hyon, Allaart, Cornelia F, Furst, Daniel E., Kaleb Michaud, Heijde, D. van der, van der Heijde, D., George Wells, Cornelia F Allaart, Furst, D., Landewe, R., Josef S Smolen, Brooks, Peter M., Allaart, Cornelia F., Sokka, Tuulikki, Maarten de Wit, David T. Felson, Peter Brooks, Verstappen, Suzan, Boers, M., Choi, H., Khanna, Dinesh, Khanna, D., Aletaha, D., Strand, Vibeke, Bombardieri, Stefano, Kvien, Tore K., Wolfe, F, Boers, Maarten, Stefano Bombardieri, Listing, J., Tugwell, P, Zhang, B., Joan Bathon, Lee S. Simon, Barbara White, Richards, Pamela, Wolfe, Frederick, Sokka, T., Maxime Dougados, Angela Zink, van Tuyl, Lilian H. D., van Tuyl, H.D., Hawker, G., Brown, A., Felson, David T., Paul Emery, Keystone, E., Bathon, Joan, Listing, Joachim, Verstappen, S., Zink, Angela, Combe, B., Michaud, K., Hyon Choi, Wolfe, F., Daniel Furst, Joachim Listing, Funovits, Julia, Gomez-Reino, J., de Wit, Maarten P. T., Emery, Paul, Gomez-Reino, Juan, Wells, George, Jeffrey N Siegel, Lilian H D van Tuyl, Theodore Pincus, Zink, A., Michaud, Kaleb, Marco Matucci-Cerinic, Tyndall, A., Lee S Simon, Keystone, Edward, European League Against Rheumatism,, Landewé, Robert, Emery, P., Julia Funovits, Zhang, Bi, Jeffrey N. Siegel, Maarten Boers, Van Tuyl, Lilian H D, de Wit, Maarten, Pincus, T., Hawker, Gillian, Strand, V., Edward Keystone, Frederick Wolfe, Martin-Mola, E., Pamela Montie, de Wit, M., van Tuyl, L.H.D., Tore K. Kvien, Cornelia F. Allaart, Emilio Martin-Mola, Matucci-Cerinic, Marco, Emery, P, Zhang, Bin, Tyndall, Alan, Bernard Combe, Dougados, M., Kirwan, J., David T Felson, Tugwell, Peter, Allaart, C.F., Brown, A, Juan Gomez-Reino, Vibeke Strand, Tuyl, L.H.D. van, Montie, P., Brooks, P., Peter Tugwell, Kirwan, John, Simon, Lee S., Furst, Daniel, Bombardieri, S., van der Heijde, Desirée, Dinesh Khanna, White, B., Pincus, Theodore, Wells, G., Siegel, J.N., Martin-Mola, Emilio, Tugwell, P., Felson, D.T., Desirée van der Heijde, Smolen, Josef S., Lilian H. D. van Tuyl, Smolen, J.S., Strand, V, Bin Zhang   +156 more
core   +2 more sources

IgA rheumatoid factor in rheumatoid arthritis

, 2022
Objectives Rheumatoid factor (RF) is a well-established marker for the diagnosis and classification of rheumatoid arthritis (RA). Most studies evaluated IgM RF or isotype-nonspecific total RF assays. We evaluated the added value of IgA RF in this context.
Mueller, Ruediger,, Jovancevic, Boja,, Steiner, Guenter,, Wirth, Claudine, Jese, Rok, Van Hoovels, Lieve,, Dahle, Charlotte, Sjowall, Christopher, Jacques, Peggy, Bonroy, Carolien,, Sjöwall, Christopher,, Kyburz, Diego, Bossuyt, Xavier, Van den Bremt, Stefanie, Dahle, Charlotte,, Bogaert, Laura, Sieghart, Daniela,, Aletaha, Daniel, Vanheule, Geert,, Steiner, Guenter, Cucnik, Sasa, Pullerits, Rille, Nagy, Eszter,, Van Hoovels, Lieve, Cucnik, Sasa,, Kastbom, Alf, Kiss, Emese, Pullerits, Rille,, Robbrecht, Johan, Verschueren, Patrick,, Heijnen, Ingmar,, Bernasconi, Luca,, Bernasconi, Luca, Robbrecht, Johan,, Jovancevic, Boja, Bogaert, Laura,, Bonroy, Carolien, Benkhadra, Farid, Kastbom, Alf,, Kiss, Emese,, Van Liedekerke, Ann, Nagy, Eszter, Studholme, Lucy, Heijnen, Ingmar, Mueller, Ruediger, Aletaha, Daniel,, Bossuyt, Xavier,, Benkhadra, Farid,, Sieghart, Daniela, Vander Cruyssen, Bert,, Jese, Rok,, Verschueren, Patrick, Studholme, Lucy,, Wirth, Claudine,, Vander Cruyssen, Bert, Vanheule, Geert, Van Liedekerke, Ann,, Kyburz, Diego,, Jacques, Peggy,, Van den Bremt, Stefanie,   +59 more
core   +1 more source

The association between systemic inflammation as measured by calprotectin and autoantibody load in rheumatoid arthritis

Arthritis &Rheumatology, Accepted Article.
Background Plasma calprotectin is a marker of neutrophil activity. Its relation to the clinical phenotype and autoantibodies in rheumatoid arthritis (RA) is only partly understood. We therefore aimed to investigate the association between calprotectin and clinical parameters, CRP, ESR, anti‐CCP2 and other anti‐modified protein autoantibodies (AMPAs) in
Caroline Grönwall, Linda Mathsson Alm, Helga Westerlind, Isabel Gehring, Nasim Ghasemzadeh, Niels Steen Krogh, Siri Lillegraven, Espen Haavardsholm, Martina Johannesson, Tore K. Kvien, Johan Rönnelid, Tue Wenzel Kragstrup, Bente Glintborg, Merete Lund Hetland, Hilde Berner Hammer, The Danish Rheumatologic Biobank Study Group, Swedish Rheumatology Quality Register Biobank Study Group(SRQb), Johan Askling, Oliver Hendricks, Estrid Høgdall, Dorte Vendelbo Jensen, Heidi Lausten Munk, Jens Kristian Pedersen, Torkell Ellingsen, Anne Gitte Loft, Ellen‐Margrethe Hauge, Salome Kristensen, Lene Dreyer, Asta Linauskas, Søren Jacobsen, Carl Turesson, Solbritt Rantapää Dahlqvist, Lena Björkman, Alf Kastbom, Eva Baecklund   +34 more
wiley   +1 more source