The socioeconomic cost of chronic rhinosinusitis study.
Rhinology, 2020 INTRODUCTION Chronic rhinosinusitis (CRS) is highly prevalent, affecting 11% of the population. Studies evaluating the socio-economic impact of CRS are mostly limited to the US population. Currently there is no study that has evaluated the socio-economic
Nur Wahidah Wahid +4 more
semanticscholar +1 more source
JPGN Reports, EarlyView.Abstract Objectives Eosinophilic esophagitis (EoE) is a type 2 cytokine‐mediated chronic inflammatory condition leading to esophageal dysfunction. Dupilumab blocks IL‐4 and IL‐13 signaling, which are key inflammatory mediators in EoE and other allergic disorders.
Sindhura Kasturi +6 more
wiley +1 more source
Dupilumab efficacy in uncontrolled, moderate-to-severe asthma with self-reported chronic rhinosinusitis [PDF]
, 2019 BACKGROUND: Dupilumab, a fully human monoclonal antibody, blocks the shared receptor component for IL-4 and IL-13 signaling, key drivers of type 2 inflammation.
Castro, Mario, et al,, Maspero, Jorge F
core +1 more source
Staphylococcus aureus enterotoxin B regulates prostaglandin E-2 synthesis, growth, and migration in nasal tissue fibroblasts [PDF]
, 2008 Background. Superantigens and eicosanoids are important amplifiers and regulators of inflammation in airway diseases. We therefore studied the possible influence of Staphylococcus aureus enterotoxin B ( SEB) on the cyclooxygenase ( COX) pathway and basic
Bachert, Claus +4 more
core +2 more sources
International Variation in Preoperative SNOT‐22 Scores: A Scoping Review and Exploratory Analysis
International Forum of Allergy &Rhinology, EarlyView.
Jaynelle Gao +8 more
wiley +1 more source
Long‐Term Cost Utility Analysis of Endoscopic Sinus Surgery: Analysis of 5‐Year Outcomes
The Laryngoscope, EarlyView.This study utilizes a cohort‐style Markov decision tree economic model to evaluate the long‐term (5‐year) cost‐effectiveness of endoscopic sinus surgery versus medical management for patients with chronic rhinosinusitis. The results show that the endoscopic sinus surgery strategy cost more ($63,296.27) but yielded increased quality‐adjusted life years (
Dara R. Adams +5 more
wiley +1 more source
Therapeutic Effectiveness of SNOT 22-Based Interdose Interval Adjustment of Dupilumab for Chronic Rhinosinusitis With Nasal Polyps [PDF]
Clinical and Experimental OtorhinolaryngologyObjectives. This study evaluates the enduring efficacy and patient satisfaction of dupilumab with interdose interval adjustments based on the Sino-Nasal Outcome Test (SNOT-22) in chronic rhinosinusitis with nasal polyps (CRSwNP). Methods. A retrospective
So Yeon Yoon +4 more
doaj +1 more source
Chronic Rhinosinusitis—An Update on Epidemiology, Pathogenesis and Management
Journal of Clinical Medicine, 2020 Chronic rhinosinusitis (CRS) is one of the most common chronic medical conditions worldwide, affecting all age groups [...].
S. Albu
semanticscholar +1 more source
Impact of Obesity on the Structured Histopathology of Chronic Rhinosinusitis Patients
The Laryngoscope, EarlyView.ABSTRACT Objectives Obesity is an established risk factor for asthma, which shares common inflammatory pathways with chronic rhinosinusitis (CRS). However, the link between obesity and CRS remains poorly understood. By identifying trends in the structured histopathology (SHP) of obese patients with CRS, we aim to better understand how changes in the ...
Daniel X. Ma +7 more
wiley +1 more source
Nontypeable Haemophilus influenzae biofilms: role in chronic airway infections
Frontiers in Cellular and Infection Microbiology, 2012 Like many pathogens inhabiting mucosal surfaces, nontypeable Haemophilus influenzae (NTHi) forms multicellular biofilm communities both in vitro and in various infection models.
W Edward Swords
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