This graphical abstract illustrates the novel ZFP36L1–CAMK2A regulatory axis in chronic rhinosinusitis (CRS) pathogenesis: 1. Molecular initiation: In nasal epithelial cells, the RNA‐binding protein ZFP36L1 (upregulated in CRS) directly binds to AU‐rich elements (AREs) in the 3′‐untranslated region (3′‐UTR) of CAMK2A mRNA, promoting its degradation and
Jiayi Xiong +6 more
wiley +1 more source
Intracranial Complications Following Acute Rhinosinusitis in a Pediatric Patient Requiring Surgery: A Case Report. [PDF]
Sudo T, Kamakura T, Tsuda T, Mishiro Y.
europepmc +1 more source
Elexacaftor–Tezacaftor–Ivacaftor Reduces Revision Sinus Surgery in People With Cystic Fibrosis
Elexacaftor–tezacaftor–ivacaftor (ETI) was associated with a significant decrease in the frequency and rate of endoscopic sinus surgeries in patients with cystic fibrosis. These findings suggest an improvement in CF‐related chronic rhinosinusitis outcomes following ETI and may influence future CF treatment decisions.
Amy Lin +6 more
wiley +1 more source
The knowledge, attitudes and practice of nasal irrigation among patients with rhinosinusitis: a cross-sectional study. [PDF]
Yang FL +6 more
europepmc +1 more source
Diagnosing Eosinophilic Chronic Rhinosinusitis in Excised Tissue Using Optical Coherence Tomography
This study evaluated whether optical coherence tomography (OCT) can quantify eosinophils in excised sinonasal tissue and diagnose eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP). Counts of globules resembling eosinophils on OCT images strongly correlated with eosinophils per HPF on histology, with a cutoff of 45 globules on OCT imaging ...
Ido Badash +6 more
wiley +1 more source
Systematic Review of Nasal Endoscopy Scores in Cystic Fibrosis Patients Treated With Cystic Fibrosis Transmembrane Conductance Regulator Modulators. [PDF]
Gallardo R +4 more
europepmc +1 more source
Orbital Complications of Acute Rhinosinusitis in Adulthood: Predictors of Outcome and Management
In a multicenter cohort of 213 adults with orbital complications of acute rhinosinusitis, 68% required surgery and the modified Chandler classification was the strongest predictor of treatment modality. While abscess‐related and type II complications frequently necessitated surgical management, final ophthalmologic outcomes were uniformly favorable ...
Alessandro Vinciguerra +41 more
wiley +1 more source
Neuropsychiatric Sequelae of Chronic Rhinosinusitis: A Retrospective Cohort Study Using a Multi-institutional Electronic Health Records Network. [PDF]
Zerefos I, Li Z, Napalinga KM.
europepmc +1 more source
Chronic rhinosinusitis during immune checkpoint inhibition in melanoma patients
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Yenny Angela +3 more
wiley +1 more source

