Results 251 to 260 of about 191,346 (272)

Single‐Cell Analysis of L‐Myc Expressing Neural Stem Cells and Their Extracellular Vesicles Revealed Distinct Progenitor Populations With Neurogenic Potential

Journal of Extracellular Biology, Volume 4, Issue 11, November 2025.
ABSTRACT Neural stem cell (NSC)‐based therapies offer a promising strategy to promote brain repair by delivering neurotrophic factors, supporting cell replacement, and stimulating endogenous neurogenesis following injury. While numerous studies have highlighted the protective and regenerative potential of NSCs and their extracellular vesicles (EVs ...
Patrick Pirrotte, Yate‐Ching Yuan, Nathaniel P. Hansen, Isabella Vasquez, Nan Jiang, Alejandra V. Ojeda, Eric Alsop, Melissa N. Martinez, Ritin Sharma, Meechoovet Hunsar, Benjamin Peton, Dorothy M. Palomares, Blake Brewster, Michael Barish, Corina O. Bondi, Russell C. Rockne, Tijana Jovanovic‐Talisman, Kendall Van Keuren‐Jensen, Anthony E. Kline, Margarita Gutova   +19 more
wiley   +1 more source

Molecular Encoding of Ischemic Stroke and its Resolution after Human Neural Stem Cell Therapy by Extracellular Vesicles

MedComm, Volume 6, Issue 11, November 2025.
EVs can cross the blood–brain barrier and enter systemic circulation. By analyzing EV RNA cargoes before and after stroke, and following hNSC transplantation, our study shows that EV RNAs accurately reflect stroke pathology and provide insights into how hNSCs promote stroke recovery. These findings suggest that EV RNA profiles could serve as diagnostic
Chuheng Chang, Yiqing Wang, Xiaohang Liang, Renzhi Wang, Xinjie Bao   +4 more
wiley   +1 more source

Rho GTPases and the emerging role of tunneling nanotubes in physiology and disease.

Am J Physiol Cell Physiol, 2020
Zhang S, Kazanietz MG, Cooke M.
europepmc   +1 more source

The Gut‒Liver Axis in Liver Disease: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 6, Issue 11, November 2025.
The global burden of liver disease is increasing, and gut‐liver axis dysregulation is a key driver. This article explains its mechanisms in various liver diseases and explores targeted therapeutic strategies, aiming to provide new insights into liver disease treatment.
Zhiji Chen, Siqi Liao, Suhua Wu, Siyuan Chen, Qin Tang, Li Zhou, Xiaoqin Li, Huiyi Hu, Jiayao Xu, An Zhang, Song He, Zhi‐Hang Zhou   +11 more
wiley   +1 more source

Computational model predicts function of Rho‐GTPase binding for plexin receptor GAP activity on Rap1b via dynamic allosteric changes

Nisha Bhattarai, Lindsay Morrison, Angela Gabriella Gomes, Paul B. Savage, Amita R. Sahoo, Matthias Buck   +5 more
openalex   +1 more source

Protein Kinase C Family: Structures, Biological Functions, Diseases, and Pharmaceutical Interventions

MedComm, Volume 6, Issue 11, November 2025.
Ligand–receptor binding activates PLC, which hydrolyzes the membrane lipid PIP2, generating the second messenger's IP3 and DAG. IP3 binding to ER receptors causes Ca2⁺ release. Subsequently, PKC are recruited to the membrane, which induces a conformational change in PKC, leading to the full enzymatic activation.
Yongqi Li, Yuhan Jiang, Zhengxi Hu, Shenglan Yang, Longyin Li, Chaohu Xiong, Ya Gao, Weiguang Sun, Yonghui Zhang   +8 more
wiley   +1 more source

Dysregulated mitochondrial energy metabolism drives the progression of mucosal field effects to invasive bladder cancer

The Journal of Pathology, Volume 267, Issue 3, Page 329-346, November 2025.
Abstract Multiplatform mutational and gene expression profiling complemented with proteomic and metabolomic spatial mapping were used on the whole‐organ scale to identify the molecular profile of bladder cancer evolution from field effects. Analysis of the mutational landscape identified three types of mutations, referred to as α, β, and γ.
Sangkyou Lee, Sung Yun Jung, Pawel Kuś, Jolanta Bondaruk, June Goo Lee, Roman Jaksik, Nagireddy Putluri, Khanh N Dinh, David Cogdell, Huiqin Chen, Yishan Wang, Jiansong Chen, Neema Navai, Colin Dinney, Cathy Mendelsohn, David McConkey, Richard R Behringer, Charles C Guo, Peng Wei, Marek Kimmel, Bogdan Czerniak   +20 more
wiley   +1 more source

Integrative Transcriptomic and Phosphoproteomic Analysis Reveals Key Components of the SnRK1 Signaling Network in Rice

Plant Direct, Volume 9, Issue 11, November 2025.
ABSTRACT SnRK1 is an evolutionarily conserved protein kinase belonging to the SNF1/AMPK family of protein kinases that is central to adjusting growth in response to the energy status. Numerous studies have shown adaptive and developmental roles of SnRK1, but the understanding of the SnRK1 signaling network in monocots is limited.
Maria C. Faria‐Bates, Chandan Maurya, K. Muhammed Jamsheer, Vibha Srivastava   +3 more
wiley   +1 more source

RGA2, a putative rho-type GTPase-activating protein, is regulated by the transcription factor Tec1 during filamentous growth of Saccharomyces cerevisiae

, 1999
Yukiko Ueno
openalex   +1 more source

Prenatal alcohol exposure perturbs the development of radial glial cells in the fetal olfactory bulb

Alcohol, Clinical and Experimental Research, Volume 49, Issue 11, Page 2494-2501, November 2025.
Prenatal alcohol exposure affects the development of radial glial cells (RGCs) in the embryonic mouse olfactory bulb. Ethanol administered at embryonic day 11, a time point when RGCs generate the largest number of mitral cells, caused G2/M arrest in RGCs, delaying their progression to mitosis and subsequent neuronal differentiation.
Yuka Imamura Kawasawa, Kazue Hashimoto‐Torii, Masaaki Torii, Fumiaki Imamura   +3 more
wiley   +1 more source