Results 261 to 270 of about 191,346 (272)

Targeting TRPV4 to restore glymphatic system function and alleviate cerebral edema in ischemic stroke

Brain Pathology, Volume 35, Issue 6, November 2025.
After ischemic stroke, TRPV4 activation induces cerebral edema through the TRPV4‐RhoA‐MMP9 axis: RhoA upregulates MMP9, which cleaves β‐DG to impair membrane anchoring. Subsequent β‐DG loss triggers AQP4 depolarization, disrupting GS‐mediated water homeostasis.
Yongchuan Li, Haiping Zhou, Jiaxin Xie, Mingjia Yu, Guanyu Ye, Yuzhen Zhang, Zhentong Li, Kunxue Zhang, Jingwen Wu, Sheng Xiao, Shuxin Zeng, Yuan Chang, Kaibin Huang, Suyue Pan   +13 more
wiley   +1 more source

ROS‐Driven PKCζ Signaling as a Widely Involved Mechanism for Cancer Cell Motility and Metastasis

Cancer Science, Volume 116, Issue 11, Page 3027-3039, November 2025.
This study reveals that the enhancement of cancer cell motility by diverse bioactive molecules—including growth factors, hormones, and tissue factors—is mediated through a common intracellular mechanism involving reactive oxygen species (ROS) and the PKCζ/Rho GTPase signaling pathway.
Yasushi Sato, Maki Tanaka, Naoko Kitamura, Naoko Araki, Wataru Kurata, Akiko Sasaki, Yukimi Seo, Kageaki Kuribayashi, Shuzo Kobayashi, Yoshiro Niitsu   +9 more
wiley   +1 more source

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RHO GTPases: from new partners to complex immune syndromes

Nature reviews. Immunology, 2021
Rana El Masri, J. Delon
semanticscholar   +1 more source

Rho GTPases and the actin cytoskeleton.

Science, 1998
A. Hall
semanticscholar   +1 more source

Rho GTPases in cell biology

Nature, 2002
S. Étienne-Manneville, A. Hall
semanticscholar   +1 more source

Rho GTPases: biochemistry and biology.

Annual Review of Cell and Developmental Biology, 2005
A. Jaffe, Alan Hall
semanticscholar   +1 more source

GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

Nature reviews. Molecular cell biology, 2005
K. Rossman, C. Der, J. Sondek
semanticscholar   +1 more source

Mammalian Rho GTPases: new insights into their functions from in vivo studies

Nature reviews. Molecular cell biology, 2008
S. Heasman, A. Ridley
semanticscholar   +1 more source

Regulating Rho GTPases and their regulators

Nature reviews. Molecular cell biology, 2016
R. G. Hodge, A. Ridley
semanticscholar   +1 more source

RHO–GTPases and cancer

Nature Reviews. Cancer, 2002
E. Sahai, C. Marshall
semanticscholar   +1 more source