Results 211 to 220 of about 52,817 (240)
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RhoA-Mediated Signaling in Mechanotransduction of Osteoblasts
Connective Tissue Research, 2012Osteoblasts play a pivotal role in load-driven bone formation by activating Wnt signaling through a signal from osteocytes as a mechanosensor. Osteoblasts are also sensitive to mechanical stimulation, but the role of RhoA, a small GTPase involved in the regulation of cytoskeleton adhesion complexes, in mechanotransduction of osteoblasts is not ...
Kazunori, Hamamura +6 more
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Activated RHOA and peripheral axon regeneration
Experimental Neurology, 2008The regeneration of adult peripheral neurons after transection is slow, incomplete and encumbered by severe barriers to proper regrowth. The role of RHOA GTPase has not been examined in this context. We examined the expression, activity and functional role of RHOA GTPase and its ROK effector, inhibitors of regeneration, during peripheral axon outgrowth.
C, Cheng +9 more
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Macrophages and RhoA Pathway in Transplanted Organs
2017RhoA is a small GTPase that, via its downstream effectors, regulates a variety of cell functions such as cytokinesis, cell migration, vesicular trafficking, and phagocytosis. As such the RhoA pathway is also pivotal for proper functioning of immune cells including macrophages.
Liu, Yianzhu +4 more
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The role of RhoA in corticogenesis
2012Insights into the developmental processes during which the brain forms from the neuroepithelium may provide a deeper understanding how the brain works. The Rho family of small GTPases is known for its many cell biological functions such as regulation of the cytoskeleton, gene expression, cell migration, adhesion, cell polarity and the cell cycle.
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RhoA/Rho-Kinase in the Cardiovascular System
Circulation Research, 2016Twenty years ago, Rho-kinase was identified as an important downstream effector of the small GTP-binding protein, RhoA. Thereafter, a series of studies demonstrated the important roles of Rho-kinase in the cardiovascular system. The RhoA/Rho-kinase pathway is now widely known to play important roles in many cellular functions, including contraction ...
Hiroaki, Shimokawa +2 more
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Degradation of RhoA by Smurf1 Ubiquitin Ligase
2006The Rho family of small GTPases plays a key role in the dynamic regulation of the actin cytoskeleton that underlies various important cellular functions such as shape changes, migration, and polarity. We found that Smurf1, a HECT domain E3 ubiquitin ligase, could specifically target RhoA but not Cdc42 or Rac1 for degradation.
Hong-Rui, Wang +5 more
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Exercise, RhoA and Cardioprotection [PDF]
, 2011 Regular exercise prevents cardiovascular disease (CVD), however the molecular mechanisms to explain the benefits are not well understood. Recent evidence suggests that exercise-induced changes in endothelial cell morphology and function may play a major role in preventing CVD.
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