Results 221 to 230 of about 230,058 (336)

Hyperviscous Diabetic Bone Marrow Niche Impairs BMSCs Osteogenesis via TRPV2‐Mediated Cytoskeletal‐Nuclear Mechanotransduction

open access: yesAdvanced Science, EarlyView.
Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen   +8 more
wiley   +1 more source

A Highly Photostable Near‐Infrared Labeling Agent Based on a Phospha‐rhodamine for Long‐Term and Deep Imaging [PDF]

open access: bronze, 2018
Marek Grzybowski   +8 more
openalex   +1 more source

TBK1 Induces the Formation of Optineurin Filaments That Condensate with Polyubiquitin and LC3 for Cargo Sequestration

open access: yesAdvanced Science, EarlyView.
Phosphorylation of Optineurin by TBK1 induces the formation of filaments that condensate upon binding to linear polyubiquitin. Membrane‐anchored LC3 partitions into these condensates, suggesting that phase separation of filamentous Optineurin with ubiquitylated cargo promotes the sequestration of cargo and its subsequent alignment with LC3‐positive ...
Maria G. Herrera   +10 more
wiley   +1 more source

Engineering Dimensional Configuration of Single‐Atom S‐Cu‐S Sites as Reversible Electron Station for Enhanced Peroxidase‐Mimicking

open access: yesAdvanced Science, EarlyView.
L‐cysteine triggers auto‐assembly of POD‐like 3D biomimetic S‐Cu‐S single‐atom nanozymes on MoS2 (MoCC). MoCC shows 16.3‐fold higher catalytic velocity and 17.9‐fold greater affinity than HRP, enabling efficient •OH generation via enhanced electron inversion and transfer.
Wenjie Ma   +12 more
wiley   +1 more source

Optimizing multifunctional fluorescent ligands for intracellular labeling. [PDF]

open access: yesProc Natl Acad Sci U S A
Kumar P   +9 more
europepmc   +1 more source

Epithelium‐Inspired, Ultrahigh‐Toughness, Ultralow‐Hysteresis, and Highly Compressible Polymer Hydrogels as Self‐Powered, Visual, and Underwater Strain Sensors

open access: yesAdvanced Science, EarlyView.
Inspired by epithelial tissue, epithelium‐like structure hydrogels are synthesized. The as‐prepared hydrogels exhibit ultrahigh toughness, ultralow hysteresis, and ultrahigh compressibility, which can be utilized as self‐powered and visual strain sensors.
Yutang Zhou   +4 more
wiley   +1 more source

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