Results 111 to 120 of about 9,778,451 (246)

Deciphering Anti‐Cancer Drug Efficacy Through Nanomechanical Vibrations in Living Gastric Cancer Organoids

Advanced Science, EarlyView.
This study developed an efficacy assessment platform that integrates patient‐derived gastric cancer organoids, atomic force microscopy (AFM)‐based nanomechanical vibration detection, deep learning analysis, and organoid mechanical modeling. It detects picomolar drug effects within 0.1 s signal, achieves 97% classification accuracy, and offers non ...
Ting Zhang, Qiubo Chen, Shihai Lan, Liang Zhu, Shuaiyu Liu, Yan Xia, Yalu Zhang, Hanhui Yao, Yongman Liu, Shangquan Wu, Qingchuan Zhang   +10 more
wiley   +1 more source

Bending‐Stable Pressure Sensor Based on Natural Wood Nanofibers for Ultra‐Low Detection Limit

Advanced Science, EarlyView.
A wood nanofiber‐based flexible pressure sensor with intrinsic bending‐stable performance is developed through a porous electrospun architecture and interdigital electrode design. The device exhibits an ultra‐low detection limit and stable operation under deformation for physiological monitoring and spatial sensing, providing a sustainable strategy for
Xu Zeng, Zhengnan Sun, Yilin Wang, Yao Tan, Ranran Xu, Beomjoon Kim, Juergen Brugger, Xiaosheng Zhang   +7 more
wiley   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Rate versus rhythm control in atrial fibrillation in the geriatric population — clinical outcomes, comorbidities, and therapeutic implications

Folia Cardiologica
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, with a prevalence exceeding 10% in individuals > 75 years of age. In elderly patients, AF is associated with an increased risk of stroke, heart failure, hospitalization, and ...
Michał Tarnowski, Paulina Brania, Martyna Wałcerz-Bajorska, Kinga Furtak, Piotr Sobolewski, Iwona Gorczyca-Głowacka   +5 more
doaj   +1 more source

Rhythm and movement : an objective analysis of their association with music aptitude [PDF]

, 1984
It was the purpose of this study to investigate the nature and characteristics of rhythm aptitude and its part in developmental music aptitude. Group lessons in rhythm and movement were administered to primary-age students to investigate the effect of ...
NC DOCKS at The University of North Carolina at Greensboro, Moore, Janet L.S.   +1 more
core  

Developing Soft Interconnected Microchannel Network for 2D Skin‐Like Actuator

Advanced Science, EarlyView.
A soft interconnected network of microchannels is proposed to develop new pneumatic actuators for future bio‐inspired soft robots. Simultaneous stimulation of this network generates regional asymmetric strains in walls of microchannels whose interaction across the entire surface leads to bending curvatures in multidimensions.
John Noee, Mohammad Akbari, Josephine Perto Justsen, Ulrich Doll, Rassoul Tabassian   +4 more
wiley   +1 more source

Atrial Fibrillation Postoperative Cardiac Surgery: A Literature Review of Recurrence, Stroke Risk, and Management Approaches

The Heart Surgery Forum
Postoperative atrial fibrillation (POAF) is the most common complication following cardiac surgery. While often considered a transient and expected complication, recent evidence suggests that POAF is associated with an increased risk of recurrence ...
Ahmed Osman, François-Adrien Duvauchelle, Amale Ghandour, Oliver Lee, Dominique Shum-Tim   +4 more
doaj   +1 more source

Melatonin secretion in a strictly subterranean mammal, the Damaraland mole-rat (Cryptomys damarensis) [PDF]

, 2003
Subterranean mammals inhabit an environment that is normally devoid of light and are therefore deprived of photoperiodic information that can be used to time important life-history events.
N. C. Bennett, Fleming, P.A., B. Malpaux, A. J. Molteno, Bennett, N.C., Richter, T.A., Molteno, A.J., P. A. Fleming, Malpaux, Benoit, Malpaux, B., T. A. Richter   +10 more
core  

Machine Learning‐Driven Design of Multicomponent Bone Inorganic Matrix Mimicking Scaffolds for Osteogenesis Enhanced by Neurogenesis

Advanced Science, EarlyView.
Schematic illustration of development of experimental datasets and algorithm models, screening and preparation of the scaffolds and their applications in vivo. ABSTRACT Bone defects require materials with osteogenic, neurogenic, and angiogenic activity, yet designing such materials within high‐dimensional compositional spaces remains challenging. Here,
Kunlu Lin, Ying Yang, Chuyao Zhou, Hanyue Mao, Zhiquan Zhang, Libangxi Liu, Xiaoying Yu, Haoming Liu, Long Liu, Xiaoyan Wang   +9 more
wiley   +1 more source

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

Advanced Science, EarlyView.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong, Minhao Liu, Mingming Zheng, Jizhou Jia, Ziyan Zhu, Guang Kong, Jie Liu, Juan Wang, Wenbo Li, Qingyuan Wang, Qian Zhu, Peiran Chan, Tao Qin, Jiayang Wu, Yongjie Zhang, Chunming Tang, Cong Li, Jin Fan   +17 more
wiley   +1 more source