Results 181 to 190 of about 9,778,451 (246)

The diagnostic value of the circadian rhythm gene KLF10 in anxiety‐depressive disorders and its neuroimmune regulatory mechanisms

Animal Models and Experimental Medicine, EarlyView.
This graphical abstract illustrates the protective role and molecular mechanism of the circadian rhythm‐related gene KLF10, identified as a diagnostic biomarker and therapeutic target in anxiety‐depressive disorder. Model establishment and phenotypes: An anxiety‐depression model was successfully established by chronic restraint stress combined with ...
Anlan Liu, Weifeng Guo, Jianxiang Li, Tiange Zhang, Dan Xu   +4 more
wiley   +1 more source

Convergent Hybrid Ablation and Concomitant Left Atrial Appendage Exclusion for Stroke Prevention and Rhythm Control in Persistent Atrial Fibrillation. [PDF]

J Clin Med
Toma YR, Damgaard S, Carranza CL.
europepmc   +1 more source

T Cell‐Mediated Targeting of Interneurons in Mice Shapes Hippocampal Remodeling and Epilepsy

Annals of Neurology, EarlyView.
Objective Autoimmune encephalitis (AE) is associated with autoantibodies targeting distinct neuronal populations. In AE, antibodies against glutamate decarboxylase 65 (GAD65), expressed in GABAergic interneurons, are frequently detected. In GAD65‐AE, hippocampal biopsies often show infiltrates of CD8+ cytotoxic T cells (CTLs), suggesting a prominent T ...
Daniel S. Galvis‐Montes, Lukas Henning, Karen M. J. van Loo, Rainer Surges, Susanne Schoch, Albert J. Becker, Julika Pitsch   +6 more
wiley   +1 more source

Effects of Rhythm Control versus Rate Control on Atrial Fibrillation and Frailty Development in Older Patients: Protocol for the Cardioversion of Atrial Fibrillation and Frailty in the Elderly (CAFFE) Study, an Observational, Prospective Cohort Study. [PDF]

JMIR Res Protoc
Berni E, De Angelis V, Santamaria E, Mengozzi A, Di Serio C, Spanalatte G, Biagioli M, Tariello A, Niccolini M, Cagnoni C, Da Silva Nakano DM, Alla Viligiardi G, Capacci M, Ungar A, La Marca G, Diemberger I, Virdis A, Fumagalli S.   +17 more
europepmc   +1 more source

Hippocampal Seizure‐Related Burden is Associated with Accelerated Long‐Term Forgetting in Focal Epilepsy

Annals of Neurology, EarlyView.
Objective Memory impairment is a frequent comorbidity of focal epilepsy, incompletely explained by seizure frequency or structural pathology. Ictal and postictal hippocampal dysfunction disrupt memory processes, but their cumulative impact remains poorly quantified.
Ionuț‐Flavius Bratu, Isabelle Lambert, Olivier Felician, Samuel Medina Villalon, Agnès Trébuchon, Fabrice Bartolomei   +5 more
wiley   +1 more source

Beyond Rhythm Control: Health-Related Quality of Life and Attention-Behavioral Outcomes After Catheter Ablation in Children with Supraventricular Tachycardia. [PDF]

Healthcare (Basel)
Doğaç T, Elkıran Ö, Maraş SA, Öncül M, Doğan Ö.   +4 more
europepmc   +1 more source

Atrial fibrillation recurrence after rhythm control: gaps in outpatient risk factor management in a single-centre retrospective cohort study. [PDF]

BMC Cardiovasc Disord
Murphy D, Strong K, Graby J, Rodrigues JCL, Thompson D, Khavandi A.   +5 more
europepmc   +1 more source

Obesity‐Related Inflammation Masks Iron Deficiency in US Women

American Journal of Hematology, EarlyView.
Sixtus Aguree, Sai Chakrri Tadikonda
wiley   +1 more source

In Silico to In Cerebro—Development of the Orexin Receptor Antagonist “Photorexant” for Photomodulation In Vitro and in Mouse Brains

Angewandte Chemie International Edition, EarlyView.
Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

The Cost Utility of Rhythm Control Treatment Sequences in Patients with Atrial Fibrillation: Anti-arrhythmic Drugs Versus Catheter Ablation. [PDF]

Pharmacoeconomics
Huygens S, Versteegh M, Hemels M, Linz D, Rienstra M, Yap SC.   +5 more
europepmc   +1 more source