Results 91 to 100 of about 48,825 (277)
Effect of hydroxyurea on ribonucleotide reductase [PDF]
Biochemical and Biophysical Research Communications, 1968 Peer Reviewed ; http://deepblue.lib.umich.edu/bitstream/2027.42/33096/1/0000482 ...
openaire +4 more sources
Thioredoxin and glutaredoxin-mediated redox regulation of ribonucleotide reductase.
World Journal of Biological Chemsitry, 2014 Ribonucleotide reductase (RNR), the rate-limiting enzyme in DNA synthesis, catalyzes reduction of the different ribonucleotides to their corresponding deoxyribonucleotides.
R. Sengupta, A. Holmgren
semanticscholar +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Outcomes for relapsed Ewing sarcoma remain consistently poor. Continued efforts to consider creative new approaches for the treatment of relapsed Ewing sarcoma are needed. The Children's Oncology Group Bone Tumor Committee convened a New Strategies for Ewing Sarcoma Task Force to systematically evaluate agents for inclusion in future Phase II ...
Jessica D. Daley +17 more
wiley +1 more source
DNA damage repair proteins across the Tree of Life
iScience, 2023 Summary: Genome maintenance is orchestrated by a highly regulated DNA damage response with specific DNA repair pathways. Here, we investigate the phylogenetic diversity in the recognition and repair of three well-established DNA lesions, primarily ...
Emily Nischwitz +8 more
doaj
Reversible, long-range radical transfer in E. coli class Ia ribonucleotide reductase.
Accounts of Chemical Research, 2013 Ribonucleotide reductases (RNRs) catalyze the conversionof nucleotides to 2'-deoxynucleotides and are classified on the basis of the metallo-cofactor used to conduct this chemistry.
E. Minnihan, D. Nocera, J. Stubbe
semanticscholar +1 more source
The Prostate, EarlyView.ABSTRACT Background N‐terminus 15 amino acid (MC16) of Annexin A1 (ANXA1) is an effective therapeutic target for tumors and tumor vasculature as it specifically localizes to the cell surface of tumor cells and tumor vascular endothelial cells. We identified the d‐type peptide (hpnevrs, dhp7) by mirror‐image phage display targeting l‐type MC16 and ...
Kai Ozaki +8 more
wiley +1 more source
On‐Chip De Novo Production of mRNA Vaccine in Lipid Nanoparticles
Small, EarlyView.A microfluidic platform integrates mRNA synthesis, purification, and LNPs formulation in a continuous, streamlined process. DNA templates are transcribed on‐chip, producing mRNA that is immediately purified and encapsulated into LNPs. This approach enables rapid, scalable production of mRNA‐LNP formulations for research or therapeutic applications ...
Shai Zilberzwige‐Tal +13 more
wiley +1 more source
Nature Communications, 2017 Cytidine deaminase (CDA) deficiency leads to genome instability. Here the authors find a synthetic lethal interaction between CDA and the microtubule-associated protein Tau deficiencies, and report that Tau depletion affects rRNA synthesis ...
Elias Bou Samra +9 more
doaj +1 more source
Acute kidney injury and iron metabolism: A narrative review focusing on pathophysiology and therapy
Smart Molecules, EarlyView.Schematic illustration of acute kidney injury and iron metabolism (By Figdraw). Image for iron metabolism, including uptake, storage, utilization, export: Reproduced with permission. Abstract Acute kidney injury (AKI) represents a substantial challenge to public health and is characterized by elevated occurrence and fatality rates.
Xinyu Tan +4 more
wiley +1 more source