Results 121 to 130 of about 48,825 (277)

Machine Learning‐Augmented Molecular Dynamics Simulations (MD) Reveal Insights Into the Disconnect Between Affinity and Activation of ZTP Riboswitch Ligands

Angewandte Chemie, Volume 137, Issue 31, July 28, 2025.
This study combines computational and experimental approaches to study how natural and synthetic small molecules interact with the ZTP riboswitch, a bacterial RNA element that regulates gene expression. Using chemical synthesis, biochemical approaches, and artificial intelligence augmented MD simulations, we analyze both ligand binding and riboswitch ...
Christopher R. Fullenkamp, Shams Mehdi, Christopher P. Jones, Logan Tenney, Patricio Pichling, Peri R. Prestwood, Adrian R. Ferré‐D'Amaré, Pratyush Tiwary, John S. Schneekloth   +8 more
wiley   +2 more sources

Mitochondrial Dysfunction in Aging: Future Therapies and Precision Medicine Approaches

MedComm – Future Medicine, Volume 4, Issue 3, September 2025.
Mitochondria play a critical role in aging and aging‐related diseases. This review systematically explores the mechanisms underlying mitochondrial deterioration during aging and highlights innovative therapeutic strategies for these mitochondrial problems.
Lanlan Jia, Ziyu Wei, Jinyuan Luoqian, Xi Wang, Chao Huang   +4 more
wiley   +1 more source

Contributions of synaptic energetic dysfunction by microtubule dynamics and microtubule‐based mitochondrial transport disorder to morphine tolerance

British Journal of Pharmacology, Volume 182, Issue 17, Page 4058-4079, September 2025.
Abstract Background and Purpose Morphine is among the most powerful analgesic, but its long‐term use can cause tolerance. Synaptic ATP supply is critical for maintaining synaptic transmission. Microtubule‐based mitochondrial transport ensures synaptic energy supply.
Zheng Li, Jie Liu, Jie Ju, Xiaoling Peng, Wei Zhao, Jihao Ren, Xiaoqian Jia, Jihong Wang, Ye Tu, Feng Gao   +9 more
wiley   +1 more source

Optimization of Single Cell Protein Production by Candida utilis Using Juice Extracted from Pineapple Waste through Response Surface Methodology [PDF]

Malaysian Journal of Microbiology, 2005
Response surface methodology was applied to optimize protein content in Candida utilis grown in pineapple waste medium. A three-level full factorial design was used to develop a quantitative interpretation of mathematical models between the two variables
Rosma, A., Liong, M. T., Mohd. Azemi, M. N., Wan Nadiah, W. A.   +3 more
doaj  

Roles for DNA polymerase δ in initiating and terminating leading strand DNA replication

Nature Communications, 2019
DNA polymerases epsilon and delta, respectively, perform the majority of leading and lagging strand replication of the eukaryotic nuclear genome. Here the authors map the ribonucleotide fingerprints of the polymerases to show the special roles of ...
Zhi-Xiong Zhou, Scott A. Lujan, Adam B. Burkholder, Marta A. Garbacz, Thomas A. Kunkel   +4 more
doaj   +1 more source

The incorporation of cytidine 5′-monophosphate and other ribonucleotides by an enzyme preparation from rat-liver microsomes [PDF]

, 1967
MG Page, GR Haynes, H.G. Klemperer
openalex   +1 more source

Antineoplastic Effects of Thymoquinone on Pancreatic Atypical Acinar Cell Foci Treated With Azaserine

Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 8, August 2025.
The main purpose of this study was to investigate the antioxidant and anticarcinogenic effects of TQ, which has many traditional uses and is naturally found in Nigella sativa seeds, on the neoplastic changes induced by azaserine in exocrine pancreatic acinar cells.
Hasan Yildiz, Başak Hartavi
wiley   +1 more source

Plant synthetic biology‐based biofortification, strategies and recent progresses

Journal of Integrative Plant Biology, Volume 67, Issue 8, Page 1997-2004, August 2025.
This mini‐review highlights fi ve synthetic biology strategies to boost crop nutrition and alleviate the ‘hidden hunger’ resulting from vitamin and nutrient defi ciencies. These approaches offer precise, sustainable ways to engineer nutrient‐rich plants, providing innovative solutions to global malnutrition through biofortifi cation.
Kai Wang, Zhongchi Liu
wiley   +1 more source

Remote Control of Eukaryotic Gene Expression by a Modular Ultrasound‐Responsive RNA Toolkit

Angewandte Chemie, Volume 137, Issue 29, July 14, 2025.
A modular RNA‐based sonogenetic toolkit enables remote control of gene expression in eukaryotes by releasing small molecule modulators from ultrasound‐responsive carriers. These modulators activate engineered mRNA elements such as riboswitches, leading to tunable protein expression.
Fahimeh Charbgoo, Aman Ishaqat, Junlin Chen, Fabian Wiertz, Adrian Kuzmanović, Matthias Bartneck, Fabian Kiessling, Andreas Herrmann   +7 more
wiley   +2 more sources

Rapid and reliable RNA resonance assignment by combining chemical and enzymatic stable isotope labeling

Journal of Magnetic Resonance Open, 2022
In this work a rapid RNA assignment approach by combining chemical and enzymatic 13C and 15N stable isotope labeling is introduced. We exemplify the assignment strategy for imino N1H1 purine and N3H3 pyrimidine and aromatic C6H6 pyrimidine, C8H8 purine ...
David Klingler, Matthias Huber, Martin Tollinger, Christoph Kreutz   +3 more
doaj