Results 231 to 240 of about 77,265 (266)

Ribonucleotide Reductases

Annual Review of Biochemistry, 2006
Ribonucleotide reductases (RNRs) transform RNA building blocks to DNA building blocks by catalyzing the substitution of the 2′OH-group of a ribonucleotide with a hydrogen by a mechanism involving protein radicals. Three classes of RNRs employ different mechanisms for the generation of the protein radical. Recent structural studies of members from each
Pär, Nordlund, Peter, Reichard
openaire   +2 more sources

RNAs Containing Carbocyclic Ribonucleotides

Organic Letters, 2021
Toward the goal of evaluation of carbocyclic ribonucleoside-containing oligonucleotide therapeutics, we developed convenient, scalable syntheses of all four carbocyclic ribonucleotide phosphoramidites and the uridine solid-support building block. Crystallographic analysis confirmed configuration and stereochemistry of these building blocks.
Masaaki Akabane-Nakata, Tyler Chickering, Joel M. Harp, Mark K. Schlegel, Shigeo Matsuda, Martin Egli, Muthiah Manoharan   +6 more
openaire   +2 more sources

Reduction of Ribonucleotides

Annual Review of Biochemistry, 1979
PERSPECTIVES AND SUMMARY 1 33 RIBONUCLEOTIDE REDUCTASE FROM ES CHERICHIA COLI 136 Structural Aspects 136 Reaction Mechanism ....... .. ..... ......... ..... ... ...... ... ... ... ....... .. ..... .. ... ..... ... . 138 Allosteric Control 1 39 Hydrogen Transport System 140 RIBONUCLEOTIDE REDUCING SYSTEMS INDUCED BY BACTERIOPHAGES .... . . .
L, Thelander, P, Reichard
openaire   +2 more sources

Carbocyclic glycinamide ribonucleotide is a substrate for glycinamide ribonucleotide transformylase

Archives of Biochemistry and Biophysics, 1988
The carbocyclic analog of glycinamide ribonucleotide has been synthesized from the racemic parent trihydroxy cyclopentyl amine (B.L. Kam and N.J. Oppenheimer (1981) J. Org. Chem. 46, 3268-3272). This analog was accepted as a substrate (Km = 18 microM, Vmax = 0.23 mM/min) by mammalian glycinamide ribonucleotide transformylase (EC 2.1.2.2) with an ...
C A, Caperelli, M F, Price
openaire   +2 more sources

Isolation of a multifunctional protein with aminoimidazole ribonucleotide synthetase, glycinamide ribonucleotide synthetase and glycinamide ribonucleotide transformylase activities: characterization of the aminoimidazole ribonucleotide synthetase

Biochemistry, 1986
5-Aminoimidazole ribonucleotide (AIR) synthetase, glycinamide ribonucleotide (GAR) synthetase, and GAR transformylase activities from chicken liver exist on a single polypeptide of Mr 110,000 [Daubner, C. S., Schrimsher, J. L., Schendel, F. J., Young, M., Henikoff, S., Patterson, D., Stubbe, J., & Benkovic, S. J.
J L, Schrimsher, F J, Schendel, J, Stubbe   +2 more
openaire   +2 more sources

Glycinamide ribonucleotide analogue probes for glycinamide ribonucleotide transformylase

Bioorganic Chemistry, 1991
Abstract Glycinamide ribonucleotide (GAR) transformylase catalyzes the conversion of glycinamide ribonucleotide and 10-formyltetrahydrofolate to formylglycinamide ribonucleotide and tetrahydrofolate. This reaction constitutes the third step in de novo purine biosynthesis.
Carol A. Caperelli, B.Bobert McKellar
openaire   +1 more source

8-azidoadenosine and ribonucleotide reductase

Biochemical and Biophysical Research Communications, 1992
Inhibitors of ribonucleotide reductase are potential antiproliferative agents, since they deplete cells from DNA precursors. Substrate nucleoside analogues, carrying azido groups at the base moiety, are shown to have strong cytostatic properties, as measured by the inhibition of the incorporation of thymidine into DNA.
B, Roy, M, Lepoivre, J L, Decout, J, Lhomme, M, Fontecave   +4 more
openaire   +2 more sources

Ribonucleotide reductase from saccharomyces cerevisiae

Biochemical and Biophysical Research Communications, 1970
Partially purified ribonucleotide reductase from Saccharomyces cerevisiae was unstable in solution; however, enzyme activity could be maintained by quick-freezing and storage at low temperatures. The reduction of CDP was stimulated by ATPMg++, and maximal activity was obtained with E.
E, Vitols, V A, Bauer, E C, Stanbrough
openaire   +2 more sources

Regulation of Ribonucleotide Reductase

1981
Publisher Summary This chapter discusses the regulation of ribonucleotide reductase. Ribonucleotide reductase catalyzes the first unique step of DNA synthesis by converting the four ribonucleotides to the corresponding deoxyribonucleotides. Deoxyribonucleotides are highly specialized metabolites playing only limited roles apart from their function as
openaire   +2 more sources